Temporal processing in the basal ganglia
Temporal processing in the basal ganglia
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DOI：
10.1037/0894-4105.12.1.3
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发表时间：
1998-01-01
期刊：
影响因子：
2.4
通讯作者：
Hermanowicz, N
中科院分区：
文献类型：
--
作者：
Harrington, DL;Haaland, KY;Hermanowicz, N
这项研究调查了基底节在计时操作中的作用。非痴呆的药物帕金森病(PD)患者和对照组被测试了2个运动计时任务(以300或600 ms的目标间隔控制手指的节奏)、2个时间知觉任务(持续时间感知任务，其中标准音调对之间的间隔为300或600 ms)和2个控制时间知觉任务的听觉处理(频率感知)需求和运动计时任务中的运动速率(快速敲击)的任务。利用A.M.WING和A.B.Kristofferson(1973)的模型，电机时序的总变异性被划分为反映中央计时操作的时钟分量和估计响应实施过程的随机变异性的电机延迟分量。帕金森病组在时间知觉和运动计时任务的目标间隔都受到损害。运动计时受损是由于时钟升高，而不是运动延迟变异性。这一发现涉及到基底节及其丘脑皮质连接在计时手术中的作用。
This study investigated the role of the basal ganglia in timing operations. Nondemented, medicated Parkinson's disease (PD) patients and controls were tested on 2 motor-timing tasks (paced finger tapping at a 300- or 600-ms target interval), 2 time perception tasks (duration perception wherein the interval between the standard tone pair was 300 or 600 ms); and 2 tasks that controlled for the auditory processing (frequency perception) demands of the time perception task and the movement rate (rapid tapping) in the motor-timing task. Using A.M. Wing and A.B. Kristofferson's (1973) model, the total variability in motor timing was partitioned into a clock component, which reflects central timekeeping operations, and a motor delay component, which estimates random variability due to response implementation processes. The PD group was impaired at both target intervals of the time perception and motor-timing tasks. Impaired motor timing was due to elevated clock but not motor delay variability. The findings implicate the basal ganglia and its thalamocortical connections in timing operations.