Augmentation Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Presupplementary Motor Area in Obsessive-Compulsive Disorder A Randomized Controlled Trial
Augmentation Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Presupplementary Motor Area in Obsessive-Compulsive Disorder A Randomized Controlled Trial
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DOI：
10.1097/yct.0000000000000509
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发表时间：
2018-12-01
期刊：
影响因子：
2.5
通讯作者：
Reddy, Y. C. Janardhan
中科院分区：
文献类型：
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作者：
Arumugham, Shyam Sundar;Subhasini, V. S.;Reddy, Y. C. Janardhan
目的 本研究在一项双盲随机假对照试验中，探讨了低频重复经颅磁刺激 (rTMS) 对双侧前辅助运动区 (pre-SMA) 对药物治疗反应部分/不良的强迫症 (OCD) 患者的疗效。方法 将 40 名正在接受稳定药物治疗且对药物治疗反应部分/不良的强迫症受试者随机分为 2 组（每组 n = 20），在双侧 pre-SMA 上接受主动或假低频 rTMS。 36 名患者有资格进行意向治疗分析。基线时，两组之间的相关人口统计学和临床变量没有显着差异。结果治疗3周后，两组之间的耶鲁-布朗强迫量表评分（时间*组间交互作用，F-2.48，F-84.16 = 0.80，P = 0.40）和其他次要结局指标（包括应答率、抑郁和焦虑症状）均无统计学显着差异。结论 对于 SRI 的部分/不良反应者，低频 rTMS 相对于 pre-SMA 可能无法有效作为增强剂。这项研究强调了探索强迫症替代 rTMS 方案的必要性。
Objective The current study investigated the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) over bilateral presupplementary motor area (pre-SMA) in patients suffering from obsessive-compulsive disorder (OCD) with partial/poor response to pharmacotherapy, in a double-blinded randomized sham controlled trial. Method Forty subjects with OCD, who were on stable medications with partial/poor response to pharmacotherapy were randomly divided into 2 groups (n = 20 in each group), to receive either active or sham low-frequency rTMS over bilateral pre-SMA. Thirty-six patients were eligible for intent-to-treat analysis. There was no significant difference in relevant demographic and clinical variables between the 2 groups at baseline. Results There were no statistically significant differences between the 2 groups after 3 weeks of treatment in the Yale-Brown Obsessive Compulsive Scale score (time*group interaction, F-2.48,F-84.16 = 0.80, P = 0.40) and other secondary outcome measures including responder rates and depressive and anxiety symptoms. Conclusions Low-frequency rTMS over pre-SMA may not be effective as an augmenting agent in partial/poor responders to SRIs. This study underlines the need to explore alternate rTMS protocols in OCD.