Effects of ovariectomy, 192 IgG-saporin-induced cortical cholinergic deafferentation, and administration of estradiol on sustained attention performance in rats.
Effects of ovariectomy, 192 IgG-saporin-induced cortical cholinergic deafferentation, and administration of estradiol on sustained attention performance in rats.
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DOI：
10.1037//0735-7044.113.6.1216
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发表时间：
1999-12
影响因子：
1.9
通讯作者：
Jill McGaughy;Martin Sarter
中科院分区：
文献类型：
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作者：
Jill McGaughy;Martin Sarter
雌性卵巢切除大鼠（OVX）和假OVX大鼠在一项旨在评估持续注意力的任务中接受训练。在达到渐近表现后，OVX大鼠在试验中没有表现出在模拟OVX大鼠中观察到的表现障碍（即警惕性下降）。此外，OVX大鼠在试验中的表现不受视觉干扰物通常有害影响的影响。igg皂苷诱导的基底前脑胆碱能神经元损伤导致OVX大鼠和伪OVX大鼠表现类似的损伤。在卵巢完整的大鼠中，急性而非慢性给予17 - β -雌二醇可以减轻损伤引起的最长信号相对次数的减少。这些发现表明，影响雌二醇潜在治疗效果的变量仍然知之甚少。
Female ovariectomized (OVX) and sham-OVX rats were trained in a task designed to assess sustained attention. After achieving asymptotic performance, OVX rats did not exhibit the impairment in performance over blocks of trials (i.e., the vigilance decrement) observed in sham-OVX rats. Furthermore, OVX rats' performance over blocks of trials was unaffected by the normally detrimental effects of a visual distractor. 192 IgG-saporin-induced lesions of basal forebrain cholinergic neurons resulted in similar impairments in the performance of OVX and sham-OVX rats. The acute, but not chronic, administration of 17beta-estradiol attenuated the lesion-induced decrease in the relative number of hits to longest signals exclusively in rats with intact ovaries. These findings indicate that the variables contributing to the potential therapeutic effects of estradiol remain poorly understood.