Maternal effect killing by a supergene controlling ant social organization
Maternal effect killing by a supergene controlling ant social organization
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DOI：
10.1073/pnas.2003282117
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发表时间：
2020-07-21
影响因子：
11.1
通讯作者：
Chapuisat, Michel
中科院分区：
文献类型：
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作者：
Avril, Amaury;Purcell, Jessica;Chapuisat, Michel
超基因是自然界中惊人的多态性的基础，但它们产生和持续存在的进化机制仍然是个谜。这些连锁的基因座簇可以在人群中传播，因为它们捕获了共同适应的等位基因，或者自私地扭曲了孟德尔遗传定律。在这里，我们证明了高山银蚁中与多个蚁后群体相关的超基因单倍型是一种母体效应杀手。所有杂合子蜂王的卵在没有继承这种偶合型时都不能孵化。因此，单倍型在多个蜂群中是一种自私的遗传因素，它通过导致不携带它的后代发育迟缓来增强其自身的传播。在种群水平上，这种传代比例扭曲有利于多蜂王群体的传播，而不利于与单蜂王群体相关的替代单倍型。因此，一个单倍型的自私基因驱动将影响其他形式的群体社会组织的进化动力。这个隐藏在社会超基因中的杀手表明，大的非重组基因组区域容易在生物组织的各个层面上造成各种各样的影响。
Supergenes underlie striking polymorphisms in nature, yet the evolutionary mechanisms by which they arise and persist remain enigmatic. These clusters of linked loci can spread in populations because they captured coadapted alleles or by selfishly distorting the laws of Mendelian inheritance. Here, we show that the supergene haplotype associated with multiple-queen colonies in Alpine silver ants is a maternal effect killer. All eggs from hetero-zygous queens failed to hatch when they did not inherit this hap-lotype. Hence, the haplotype specific to multiple-queen colonies is a selfish genetic element that enhances its own transmission by causing developmental arrest of progeny that do not carry it. At the population level, such transmission ratio distortion favors the spread of multiple-queen colonies, to the detriment of the alter-native haplotype associated with single-queen colonies. Hence, selfish gene drive by one haplotype will impact the evolutionary dynamics of alternative forms of colony social organization. This killer hidden in a social supergene shows that large nonrecombin-ing genomic regions are prone to cause multifarious effects across levels of biological organization.