Serum complement factor H is associated with clinical and pathological activities of patients with lupus nephritis
Serum complement factor H is associated with clinical and pathological activities of patients with lupus nephritis
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DOI：
10.1093/rheumatology/kes218
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发表时间：
2012-12-01
期刊：
影响因子：
5.5
通讯作者：
Zhao, Ming-hui
中科院分区：
文献类型：
--
作者：
Wang, Feng-mei;Yu, Feng;Zhao, Ming-hui
Objective.本研究旨在探讨LN患者血清补体因子H（CFH）水平及其与临床和病理特征的关系。本文检测了241例LN患者、38例活动期SLE患者和11例无肾损害的非活动期SLE患者及51例正常对照者的血清CFH。对241例LN患者进行CFH自身抗体和CFH Tyr 402 His检测。部分患者肾内可见CFH沉积。活动期LN患者血清CFH水平明显低于38例SLE患者和正常对照组。LN患者血清中未检测到抗CFH自身抗体，CFH Tyr 402 His在LN患者和正常对照组中的分布差异无统计学意义。肾小球CFH表达强于正常对照组。血清CFH水平与SLEDAI评分呈轻度负相关（r =-0.204，P = 0.001），与血清C3（r = 0.367，P < 0.001）和血红蛋白水平（r = 0.193，P = 0.003）正相关。LN Ⅲ级、Ⅳ-S亚类和血栓性微血管病患者的血清CFH水平最低。血清CFH水平与LN病情活动性有关。
Objective. The aim of this study was to investigate serum complement factor H (CFH) and its associations with clinical and pathological features in patients with LN.Methods. Serum CFH was detected in 241 LN patients, 38 active and 11 inactive patients with SLE without clinical evidence of renal involvement and 51 normal controls. Serum CFH autoantibodies and CFH Tyr402His were screened in the 241 LN patients. CFH deposition in kidneys was detected in some patients.Results. Serum CFH levels in patients with LN at active phase were significantly lower than in 38 SLE patients or in normal controls. No serum anti-CFH autoantibodies were detected in patients with LN, and there was no significant difference in CFH Tyr402His distribution between patients with LN and normal controls. Glomerular expression of CFH was stronger than in normal controls. Serum CFH levels were mildly negatively associated with SLEDAI scores (r = -0.204, P = 0.001) and positively associated with serum C3 (r = 0.367, P < 0.001) and haemoglobulin levels (r = 0.193, P = 0.003). Patients with LN class III, subclass IV-S and those with thrombotic microangiopathy had the lowest serum CFH.Conclusion. Serum CFH levels were associated with disease activity of LN.