Comparison of the electropharmacological effects of verapamil and propranolol in the halothane-anesthetized in vivo canine model under monophasic action potential monitoring.
Comparison of the electropharmacological effects of verapamil and propranolol in the halothane-anesthetized in vivo canine model under monophasic action potential monitoring.
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单相动作电位监测下氟烷麻醉体内犬模型中维拉帕米和普萘洛尔的电药理学作用比较。
DOI：
10.1253/jcj.64.777
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
K. Hashimoto
中科院分区：
文献类型：
--
作者：
H. Shiina;A. Sugiyama;A. Takahara;Y. Satoh;K. Hashimoto
在氟烷麻醉的犬模型中评估维拉帕米的心血管特征，并与普萘洛尔的心血管特征进行比较。维拉帕米以1、3和10μg×kg(-1)×min(-1)的速率输注(n=6)，而普萘洛尔以10μg×kg(-1)×min(-1)的固定速率给药(n=6)。每次输注进行超过30分钟，并且在每次输注开始后20-30分钟评估参数。 10μg×kg(-1)×min(-1)剂量的维拉帕米显着抑制房室结传导，轻微降低平均血压，但左心室舒张末压、左心室压力最大上冲速度、窦自律性、双积、心排血量、心室内传导、心室复极相和不应期无明显变化。普萘洛尔抑制房室结传导的程度与维拉帕米相似，但它也抑制心室内传导、窦自律性和心室收缩，增加心室不应性，并降低双积和心输出量，而测量的其他变量没有任何显着变化。这些结果表明维拉帕米可以选择性地影响房室结，普萘洛尔对多种心血管功能的抑制作用大部分是通过β-阻滞作用和直接膜效应，尽管氟烷吸入本身可能改变了药物的每种作用。用普萘洛尔缩短心室相对不应期可能显示其对折返型室性心动过速的潜在效用。
The cardiovascular profile of verapamil was assessed in the halothane-anesthetized canine model and compared with that of propranolol. Verapamil was infused at the rates of 1, 3 and 10 microg x kg(-1) x min(-1) (n=6), whereas propranolol was administered at a fixed rate of 10 microg x kg(-1) x min(-1) (n=6). Each infusion was performed over 30 min, and the parameters were assessed for 20-30 min after the start of each infusion. Verapamil in a dose of 10 microg x kg(-1) x min(-1) significantly suppressed atrio-ventricular (AV) node conduction and slightly decreased the mean blood pressure, but no significant change was detected in the left ventricular end-diastolic pressure, maximum upstroke velocity of the left ventricular pressure, sinus automaticity, double product, cardiac output, intraventricular conduction, and ventricular repolarization phase and refractoriness. Propranolol suppressed AV node conduction to an extent similar to that of verapamil, but it also inhibited intraventricular conduction, sinus automaticity and ventricular contraction, increased the ventricular refractoriness, and decreased the double product and cardiac output, without any significant change in the other variables measured. These results suggest that verapamil can selectively affect the AV node, and that the greater part of the suppressive action of propranolol on the multiple cardiovascular performance is through a beta-blocking action and direct membrane effect, although the halothane inhalation itself might have modified each of the drug's effects. The abbreviation of the relative refractory period of the ventricle by propranolol may show its potential utility for re-entry type ventricular tachycardia.
β-肾上腺素能阻滞时维拉帕米对左心室功能的影响。
DOI：
--
发表时间：
1988
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Barragry,TP;Blatchford,JW;Tuna,IC;Ring,WS
通讯作者：
Ring,WS