Biopsy features are associated with primary symptoms in interstitial cystitis: Results from the Interstitial Cystitis Database Study
Biopsy features are associated with primary symptoms in interstitial cystitis: Results from the Interstitial Cystitis Database Study
复制标题
DOI：
10.1016/s0090-4295(01)01166-9
复制
发表时间：
2001-06-01
期刊：
影响因子：
2.1
通讯作者：
Nyberg, LM
中科院分区：
文献类型：
--
作者：
Tomaszewski, JE;Landis, JR;Nyberg, LM
本研究的目的是调查间质性膀胱炎数据库（ICDB）研究中入组患者的膀胱活检特征与泌尿系统症状之间的相关性。在ICDB研究的基线筛选期间获得膀胱活检，并评价组织病理学特征。夜间排尿频率、尿急和疼痛的多变量模型被开发出来，将膀胱病变最严重区域的活检特征作为预测因子，调整重要的临床因素和临床中心变异。在204例提供活检标本的间质性膀胱炎（TC）患者中，膀胱镜病理学结果与原发性IC症状无统计学相关性（P >0.1），尽管Hunner溃疡（n = 12）的存在提示尿频。在夜间排尿频率的多变量预测模型中，调整年龄和每次排尿的最小量。4种病理特征：（1）类胰蛋白酶染色固有层肥大细胞计数;（2）尿道上皮完全消失;（3）固有层肉芽组织;（4）VIII因子（F8）染色固有层血管密度。
The purpose of this study was to investigate associations between bladder biopsy features and urinary symptoms for patients enrolled in the Interstitial Cystitis Database (ICDB) Study. Bladder biopsies were obtained during baseline screening in the ICDB Study and were evaluated for histopathologic features. Multivariable models for nighttime voiding frequency, urinary urgency, and pain were developed, incorporating biopsy features from the most diseased area of the bladder as predictors, adjusting for significant clinical factors, and clinical center variation. Among 204 interstitial cystitis (TC) patients providing biopsy specimens, cystoscopic pathology findings were not statistically associated (P >0.1 ) with primary IC symptoms, although the presence of Hunner's ulcer (n = 12) was suggestive of increased urinary frequency. Within a multivariable predictive model for nighttime voiding frequency, adjusting for age and minimum volume per void. 4 pathology features were noted: (1) mast cell count in lamina propria on tryptase stain; (2) complete loss of urothelium; (3) granulation tissue in lamina propria; and (4) vascular density in lamina propria on factor VIII (F8) stain were statistically significant (P