Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections.
Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections.
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DOI：
10.3390/ph3051374
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发表时间：
2010-05-11
期刊：
影响因子：
--
通讯作者：
Abraham WR
中科院分区：
文献类型：
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作者：
Estrela AB;Abraham WR
许多细菌生长在表面上形成生物膜。在这种结构中，它们受到很好的保护，并且通常高剂量的抗生素不能清除感染性生物膜。生物膜的形成和稳定化由可扩散的自诱导物（例如N-酰基高丝氨酸内酯、小肽、呋喃糖基硼酸二酯）介导。干扰这一过程的代谢物已经在植物、动物和微生物中被鉴定，并且合成类似物是已知的。此外，这似乎不是控制生物膜的唯一方法。已经鉴定了能够切割生物膜基质的必需组分（例如多糖或细胞外DNA）并因此削弱生物膜结构的酶。细菌也有机制溶解它们的生物膜并恢复到无菌的生活方式。只有少数化合物负责这些过程的信号是已知的，但他们可能会打开一个全新的生物膜控制线。所有这些方法都导致生物膜的破坏，但不能杀死病原体。因此，提出了生物膜破坏化合物和抗生素的组合来处理生物膜感染。在本文中，讨论了将联合收割机生物膜控制化合物和抗生素结合起来对抗生物膜感染的不同方法，以及生物膜形成和毒力之间的平衡。
Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, furanosyl borate diester). Metabolites interfering with this process have been identified in plants, animals and microbes, and synthetic analogues are known. Additionally, this seems to be not the only way to control biofilms. Enzymes capable of cleaving essential components of the biofilm matrix, e.g. polysaccharides or extracellular DNA, and thus weakening the biofilm architecture have been identified. Bacteria also have mechanisms to dissolve their biofilms and return to planktonic lifestyle. Only a few compounds responsible for the signalling of these processes are known, but they may open a completely novel line of biofilm control. All these approaches lead to the destruction of the biofilm but not the killing of the pathogens. Therefore, a combination of biofilm-destroying compounds and antibiotics to handle biofilm infections is proposed. In this article, different approaches to combine biofilm-controlling compounds and antibiotics to fight biofilm infections are discussed, as well as the balance between biofilm formation and virulence.