Obesity alters gut microbial ecology
Obesity alters gut microbial ecology
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DOI：
10.1073/pnas.0504978102
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发表时间：
2005-08-02
影响因子：
11.1
通讯作者：
Gordon, JI
中科院分区：
文献类型：
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作者：
Ley, RE;Bäckhed, F;Gordon, JI
我们分析了来自遗传性肥胖的ob/ob小鼠、瘦的ob/+小鼠和野生型同窝小鼠以及它们的ob/+母亲的远端肠道（盲肠）微生物群的5088个细菌16S rRNA基因序列，所有这些小鼠都喂食相同的富含多糖的饮食。尽管大多数小鼠肠道物种是独特的，但小鼠和人类的微生物群在门（超界）水平上是相似的，厚壁菌门和拟杆菌门占主导地位。微生物群落组成是从母亲那里遗传而来的。然而，与瘦小鼠相比，无论亲缘关系如何，ob/ob动物的拟杆菌门丰度降低了50%，厚壁菌门则相应增加。这些在整个门水平上的变化表明，在该模型中，肥胖影响肠道微生物群的多样性，并提示有意地调控群落结构可能对调节肥胖个体的能量平衡有用。
We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.