Inflammation and thrombosis in cardiovascular disease.
Inflammation and thrombosis in cardiovascular disease.
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心血管疾病的炎症和血栓形成。
DOI：
10.1097/moh.0b013e328364219d
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发表时间：
2013-09
影响因子：
3.2
通讯作者：
Smyth SS
中科院分区：
文献类型：
--
作者：
Nagareddy P;Smyth SS
本文将总结最近的观察结果，这些观察结果为心血管和其他血栓炎症疾病状态下炎症和血栓形成之间的分子和细胞联系提供了机制见解。多种疾病状况的特征在于血栓炎症状态，其中血细胞和成分与血管壁的相互作用使血栓形成和炎症途径持续存在。针对这些途径可能分别对炎症和心血管疾病有益。正在进行的临床试验应该为血栓炎症状态导致不良临床结果的假设提供更多见解。
This article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states. Several disease conditions are characterized by a thromboinflammatory state in which interactions of blood cells and components with the vascular wall perpetuate both thrombotic and inflammatory pathways. Targeting these pathways may be of benefit in inflammatory conditions and cardiovascular disease, respectively. Ongoing clinical trials should provide additional insight into the hypothesis that the thromboinflammatory state contributes to adverse clinical outcomes.