Harnessing Iron Acquisition Machinery to Target Enterobacteriaceae.
Harnessing Iron Acquisition Machinery to Target Enterobacteriaceae.
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利用铁获取机制来瞄准肠杆菌科细菌。
DOI：
10.1093/infdis/jiaa440
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Nolan,ElizabethM
中科院分区：
文献类型：
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作者：
Sargun,Artur;Gerner,RomanaR;Raffatellu,Manuela;Nolan,ElizabethM
由于外膜渗透屏障和抗生素耐药性的不断出现，革兰氏阴性菌引起的感染很难治疗。在感染过程中，革兰氏阴性病原体必须在宿主体内获取铁（一种必需营养素）。许多革兰氏阴性细菌利用基于铁载体的复杂铁获取机制，铁载体是以高亲和力结合铁的小分子。在这篇综述中，我们概述了肠杆菌科铁载体介导的铁获取，并展示了这些系统如何为预防和/或治疗细菌感染的方法的概念化和开发提供基础。致病性肠杆菌科细菌和共生微生物基于铁载体的铁吸收机制之间的差异可能导致开发出不会损害宿主微生物群的选择性“特洛伊木马”抗菌药物和免疫策略。
Infections caused by Gram-negative bacteria can be challenging to treat due to the outer membrane permeability barrier and the increasing emergence of antibiotic resistance. During infection, Gram-negative pathogens must acquire iron, an essential nutrient, in the host. Many Gram-negative bacteria utilize sophisticated iron acquisition machineries based on siderophores, small molecules that bind iron with high affinity. In this review, we provide an overview of siderophore-mediated iron acquisition inEnterobacteriaceaeand show how these systems provide a foundation for the conceptualization and development of approaches to prevent and/or treat bacterial infections. Differences between the siderophore-based iron uptake machineries of pathogenicEnterobacteriaceaeand commensal microbes may lead to the development of selective “Trojan-horse” antimicrobials and immunization strategies that will not harm the host microbiota.