Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease.
Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease.
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DOI：
10.1517/14728222.2011.575363
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发表时间：
2011-07
影响因子：
5.8
通讯作者：
Mohler PJ
中科院分区：
文献类型：
--
作者：
Curran J;Mohler PJ
在过去的十年中，锚蛋白多肽已成为心脏兴奋-收缩耦合的重要参与者。编码锚蛋白多肽的基因中功能缺失的变异曾经被认为只发挥结构作用，但它强调了这种蛋白质如何介导兴奋-收缩耦合机制中各种电成分的适当亚细胞定位。大量证据表明，这种定位的破坏是各种心肌病的主要原因，从长QT综合征到窦房结疾病，再到更常见的心律失常。本文详细介绍了锚蛋白多肽在心脏兴奋-收缩耦合和锚蛋白特异性心肌病的发展中所起的不同作用。它将进一步讨论锚蛋白多肽如何参与心肌梗死后心脏的结构和电重构。关注锚蛋白与膜结合离子通道的相互作用如何调节这些通道对刺激的反应。特别关注的是令人兴奋的新数据，这些数据可能提供独特疗法的潜力，不仅可以对抗心脏病，而且还有望更广泛地应用于各种疾病状态。连接蛋白的锚蛋白家族在心脏兴奋-收缩耦合中扮演着重要的角色。直到最近，这些蛋白质在正常心脏功能中的重要性在很大程度上还没有得到重视。对这些蛋白质如何在心脏内发挥作用的新见解为治疗心肌病提供了潜在的新途径。
Over the past ten years, ankyrin polypeptides have emerged as critical players in cardiac excitation-contraction coupling. Once thought to solely play only a structural role, loss-of-function variants in genes encoding ankyrin polypeptides have highlighted how this protein mediates the proper subcellular localization of the various electrical components of the excitation-contraction coupling machinery. A large body of evidence has revealed how the disruption of this localization is the primary cause of various cardiomyopathies, ranging from long QT syndrome 4, to sinus node disease, to more common forms of arrhythmias. This review details the varied roles that ankyrin polypeptides play in excitation-contraction coupling in the heart and the development of ankyrin-specific cardiomyopathies. It will further discuss how ankyrin polypeptides may be involved in structural and electrical remodeling of the heart, post-myocardial infarct. Attention is given to how ankyrin interactions with membrane bound ion channels may regulate these channels’ response to stimuli. Special attention is given to exciting new data, which may offer the potential for unique therapies, for not only combating heart disease, but which also holds promise for wider applications to various disease states. The ankyrin family of adapter proteins is emerging as an intimate player in cardiac excitation-contraction coupling. Until recently, these proteins have gone largely unappreciated for their importance in proper cardiac function. New insights into how these proteins function within the heart are offering potentially new avenues for therapies against cardiomyopathy.
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DOI：
10.1152/ajpheart.00756.2009
发表时间：
2010-08-01
影响因子：
4.8
作者：
Glukhov, Alexey V.;Fedorov, Vadim V.;Efimov, Igor R.
通讯作者：
Efimov, Igor R.
影响因子：
4.8
作者：
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通讯作者：
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DOI：
10.1152/ajpheart.00059.2007
发表时间：
2007-07-01
影响因子：
4.8
作者：
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通讯作者：
Mohler, Peter J.
影响因子：
5.5
作者：
BASSANI, JWM;BASSANI, RA;BERS, DM
通讯作者：
BERS, DM
影响因子：
5
作者：
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通讯作者：
Shannon TR