EVOLUTIONARY HISTORY OF THE LIGAND-GATED ION-CHANNEL SUPERFAMILY OF RECEPTORS
EVOLUTIONARY HISTORY OF THE LIGAND-GATED ION-CHANNEL SUPERFAMILY OF RECEPTORS
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DOI：
10.1016/0166-2236(95)93887-4
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发表时间：
1995-03-01
影响因子：
15.9
通讯作者：
LUNT, GG
中科院分区：
文献类型：
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作者：
ORTELLS, MO;LUNT, GG
速效配体门控离子通道（lgic）包括烟碱ACh、5-HT3、GABA(a)和甘氨酸受体。毫无疑问，它们都有一个共同的进化祖先，因此这个群体可以被认为是一个基因超家族。因为超家族的成员都是受体，我们有理由假设它们的共同祖先也一定是某种类型的受体，而且因为受体是由相似的亚基组成的，所以祖先可能是同源寡聚的。虽然我们没能找到一组在进化上与这个超家族相关的蛋白质，但对超家族内部的进化关系的分析是可能的，并且可以提供有关当今受体和神经系统本身的结构和功能进化的信息。
The fast-acting ligand-gated ion channels (LGICs) constitute a group that encompasses nicotinic ACh, 5-HT3, GABA(A) and glycine receptors. Undoubtedly, they all share a common evolutionary ancestor, and the group can therefore be considered to be a gene superfamily. Because the members of the superfamily are all receptors, it is reasonable to suppose that their common ancestor must also have been some type of receptor, and because the receptors are made of similar subunits, the ancestor was probably homo-oligomeric. Although we failed to find a group of proteins that are related evolutionarily to this superfamily, the analysis of the evolutionary relationships within the superfamily is possible and can give rise to information about the evolution of the structure and function of present-day receptors and indeed of the nervous system itself.