Gene expression networks: competing mRNA decay pathways in mammalian cells.
Gene expression networks: competing mRNA decay pathways in mammalian cells.
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DOI：
10.1042/bst0371287
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发表时间：
2009-12
影响因子：
3.9
通讯作者：
Gong C
中科院分区：
文献类型：
--
作者：
Maquat LE;Gong C
无意义介导的信使核糖核酸衰变和Staufen1介导的信使核糖核酸衰变是服务于不同目的的机械相关的途径。在本文中，我们对每种途径进行了概述。我们描述了两条道路上共有的一个因素是如何在他们的竞争中导致的。我们还解释了这两条通路之间的竞争如何有助于C2C12成肌细胞分化为多核肌管。
Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.