Influence of carrier surface fines on dry powder inhalation formulations
Influence of carrier surface fines on dry powder inhalation formulations
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DOI：
10.1080/03639040802698794
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发表时间：
2009-01-01
影响因子：
3.4
通讯作者：
Urbanetz, Nora A.
中科院分区：
文献类型：
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作者：
Boshhiha, Antesar M.;Urbanetz, Nora A.
背景：基于载体的干粉吸入制剂的性能很大程度上取决于药物和载体之间的颗粒相互作用。除颗粒大小和形状等其他因素外，相互作用伙伴的表面特性起着决定性作用。本研究旨在研究载体表面特性对含有硫酸沙丁胺醇作为药物、乳糖和甘露醇作为模型载体化合物的有序混合物体外沉积的影响。方法：采用湿倾析法去除载体表面附着的载体细粉，获得更光滑的载体表面。使用下一代冲击器研究体外沉积。结果：与含有未经处理的载体的制剂相比，通过湿倾析去除载体细粉导致体外沉积减少。这可能是由于表面光滑度的增加和高能点数量的增加造成的。
Background: The performance of carrier-based dry powder inhalation formulations strongly depends on particle interactions between the drug and the carrier. Among other factors like particle size and shape, surface properties of the interacting partners play a decisive role. This study aims at investigating the effect of carrier surface characteristics on the in vitro deposition of ordered mixtures containing salbutamol sulfate as a drug and lactose and mannitol as model carrier compounds. Methods: The wet decantation method was used to remove the carrier fines adhered to the carrier surface and to obtain smoother carrier surfaces. In vitro deposition was investigated using the Next Generation Impactor. Results: In comparison to the formulations containing untreated carriers, the removal of carrier fines by wet decantation leads to a reduced in vitro deposition. This is possibly caused by an increase in the surface smoothness and an increase in the number of high energetic spots.