Anesthesia induced retrograde amnesia is ameliorated by ephrinA5-IgG in mice: EphA receptor tyrosine kinases are involved in mammalian memory
Anesthesia induced retrograde amnesia is ameliorated by ephrinA5-IgG in mice: EphA receptor tyrosine kinases are involved in mammalian memory
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DOI：
10.1016/s0166-4328(99)00139-4
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发表时间：
2000-03-01
影响因子：
2.7
通讯作者：
McNamara, A
中科院分区：
文献类型：
--
作者：
Gerlai, R;McNamara, A
EphA 受体及其肝配蛋白 A 配体以前被认为仅在大脑的胚胎发育中发挥作用。然而，最近，这些蛋白质被证明在成年小鼠大脑中表达，主要是在海马体中，并且与海马体突触可塑性和学习有关。学习 EphA 受体介导的哪些方面尚未研究？使用恐惧调节范式，我们证明 EphA 受体在记忆中发挥作用。我们发现，训练后的手术麻醉会导致小鼠出现强烈的情境特异性逆行性遗忘症，而麻醉后 EphA 受体的激活会显着改善这种遗忘症。由于习得未受影响且表现因素未发生改变，我们认为改善是由于认知变化导致记忆力改善。我们的数据代表了 EphA 受体酪氨酸激酶受体参与哺乳动物记忆的第一批证据，这一发现为大脑中最大受体酪氨酸激酶亚家族的功能分析开辟了新途径。 (C) 2000 Elsevier Science B.V. 保留所有权利。
EphA receptors and their ephrin-A ligands were previously thought to play a role only in embryonic development of the brain. Recently, however, these proteins were shown to be expressed in the adult mouse brain, primarily in the hippocampus, and were implicated in hippocampal synaptic plasticity and learning. What aspects of learning EphA receptors mediate have not been studied? Using the fear conditioning paradigm we demonstrate that EphA receptors play roles in memory. We show that post-training surgical anesthesia leads to robust context specific retrograde amnesia in mice, and post-anesthesia activation of EphA receptors induces a significant amelioration of this amnesia. As acquisition was left unaffected and performance factors were found unaltered, we suggest that the amelioration was due to changes in cognition leading to improved memory. Our data represent the first pieces of evidence for the involvement of EphA receptor tyrosine kinase receptors in mammalian memory, a finding that opens a new avenue into the functional analysis of the largest receptor tyrosine kinase subfamily in the brain. (C) 2000 Elsevier Science B.V. All rights reserved.