Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis
Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis
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DOI：
10.5301/jva.5000151
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发表时间：
2014-01-01
影响因子：
1.9
通讯作者：
Munda, Rino
中科院分区：
文献类型：
--
作者：
Roy-Chaudhury, Prabir;Khan, Rao;Munda, Rino
目的：由于吻合口周围静脉狭窄导致动静脉内瘘不成熟是目前一个巨大的临床问题，尚无有效的治疗方法。方法：为了进一步明确参与这一过程的细胞途径，我们评估了猪 AVF 狭窄模型中不同时间点巨噬细胞浸润的模式和强度。结果：我们的结果表明，巨噬细胞在 2 d 时出现了一种早期且怪异的浸润模式，并且快速渗透。这种浸润在7天后消失。结论：我们认为这种早期且偏心的巨噬细胞浸润可能在AVF不成熟的发病机制中发挥重要作用。
Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies.Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis.Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d.Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.