Japanese B Encephalitis in the Rat
Japanese B Encephalitis in the Rat
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大鼠乙型脑炎
DOI：
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发表时间：
1951
期刊：
影响因子：
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通讯作者：
C. E. Duffy
中科院分区：
文献类型：
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作者：
C. E. Duffy
摘要1. 7日龄白化病大鼠经鼻滴注或脑内注射日本B脑炎病毒后发生致命性脑炎。2.该病毒在腹腔注射时在7天和8天大的大鼠中产生一致的致命感染。3.虽然一些12日龄的大鼠在通过脑内、腹膜内或鼻内途径接种时对病毒易感，但它们比7日龄和8日龄的大鼠更具抵抗力。4. 21日龄和27日龄的大鼠似乎对该病毒具有抗性，因为当将其脑内注射到该年龄的动物中时，其不会诱导临床上明显的感染。
Summary 1. A fatal encephalitis develops in 7-day-old albino rats following nasal instillation or intracerebral injection of Japanese B encephalitis virus. 2. The virus produces a uniformly fatal infection in 7- and 8-day-old rats when injected intraperitoneally. 3. While some 12-day-old rats are susceptible to the virus when inoculated either by the intracerebral, intraperitoneal or intranasal route they are more resistant than 7- and 8-day-old rats. 4. Rats 21 and 27 days of age appear to be resistant to the virus since when it is injected intracerebrally into animals of this age it does not induce a clinically apparent infection.