Bacterial heme-transport proteins and their heme-coordination modes.
Bacterial heme-transport proteins and their heme-coordination modes.
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DOI：
10.1016/j.abb.2008.10.013
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发表时间：
2009-01-01
影响因子：
3.9
通讯作者：
Guo M
中科院分区：
文献类型：
--
作者：
Tong Y;Guo M
有效的铁获取对于入侵微生物的生存和毒力至关重要。哺乳动物体内的大部分铁都掺入血红素中，血红素可以被某些细菌病原体掠夺作为营养铁源。细菌利用外源血红素涉及血红素或血红素蛋白与细胞表面受体的结合，然后将血红素转运到细胞中。一旦进入细胞质，血红素就会被呈递给血红素加氧酶，其中四吡咯环被裂解以释放铁。一些革兰氏阴性细菌还分泌称为血红素的细胞外血红素结合蛋白，其功能是将血红素与环境隔离。血红素转运基因通常在 Fur（铁吸收抑制因子）调节下作为基因簇进行遗传连接。这篇综述讨论了细菌血红素获取、运输和加工过程中涉及的基因簇和蛋白质，特别关注血红素协调、蛋白质结构和血红素运输背后的机制。
Efficient iron acquisition is critical for an invading microbe’s survival and virulence. Most of the iron in mammals is incorporated into heme, which can be plundered by certain bacterial pathogens as a nutritional iron source. Utilization of exogenous heme by bacteria involves the binding of heme or hemoproteins to the cell surface receptors, followed by the transport of heme into cells. Once taken into the cytosol, heme is presented to heme oxygenases where the tetrapyrrole ring is cleaved in order to release the iron. Some Gram-negative bacteria also secrete extracellular heme-binding proteins called hemophores, which function to sequester heme from the environment. The heme transport genes are often genetically linked as gene clusters under Fur (Ferric uptake repressor) regulation. This review discusses the gene clusters and proteins involved in bacterial heme acquisition, transport and processing processes, with special focus on the heme coordination, protein structures and mechanisms underlying heme transport.
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