Molecular and immunological developments in placentas.
Molecular and immunological developments in placentas.
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DOI：
10.1016/j.humimm.2021.01.012
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发表时间：
2021-05
期刊：
影响因子：
2.7
通讯作者：
Saito S
中科院分区：
文献类型：
--
作者：
Nakashima A;Shima T;Aoki A;Kawaguchi M;Yasuda I;Tsuda S;Yoneda S;Yamaki-Ushijima A;Cheng SB;Sharma S;Saito S
Cytotrophoblasts differentiate in two directions during early placentation: syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). STBs face maternal immune cells in placentas, and EVTs, which invade the decidua and uterine myometrium, face the cells in the uterus. This situation, in which trophoblasts come into contact with maternal immune cells, is known as the maternal-fetal interface. Despite fetuses and fetusderived trophoblast cells being of the semi-allogeneic conceptus, fetuses and placentas are not rejected by the maternal immune system because of maternal-fetal tolerance. The acquired tolerance develops during normal placentation, resulting in normal fetal development in humans. In this review, we introduce placental development from the viewpoint of molecular biology. In addition, we discuss how the disruption of placental development could lead to complications in pregnancy, such as hypertensive disorder of pregnancy, fetal growth restriction, or miscarriage.
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DOI：
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发表时间：
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影响因子：
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期刊：
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影响因子：
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通讯作者：
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