Cortical reorganization and associated functional motor recovery after virtual reality in patients with chronic stroke: An experimenter-blind preliminary study
Cortical reorganization and associated functional motor recovery after virtual reality in patients with chronic stroke: An experimenter-blind preliminary study
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DOI：
10.1016/j.apmr.2005.04.015
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发表时间：
2005-11-01
影响因子：
4.3
通讯作者：
Kim, TH
中科院分区：
文献类型：
--
作者：
Jung, SH;You, SH;Kim, TH
目的：研究虚拟现实（VR）对大脑皮层重组和运动恢复的影响。设计：非参数前后测设计，实验者设盲。设置：大学医学中心。参与者：5名轻偏瘫患者（年龄59.8 ± 3.4岁）被招募。干预：5名患者接受VR，每天60分钟，每周5次，持续4周。VR的目的是提供一个虚拟的康复场景的强度的做法和感觉反馈，可以系统地操纵，以提供最合适的，个性化的运动retraining program.Main结果措施：皮质激活和相关的运动恢复进行了测量之前和之后VR使用功能性磁共振成像和标准化的运动测试，分别。结果：VR前，双侧初级感觉运动皮层（SM1）、对侧运动前皮层、对侧或同侧辅助运动区均被激活。VR后，改变的激活消失，主要激活同侧SM1（P
Objective: To investigate the effects of virtual reality (VR) on cortical reorganization and motor recovery.Design: Nonparametric pre- and posttest design with experimenter blinded.Setting: University medical center.Participants: Five patients with hemiparesis (age, 59.8+/-3.4y) were recruited.Intervention: Five patients received VR for 60 minutes a day, 5 times a week for 4 weeks. VR was designed to provide a virtual rehabilitation scene where the intensity of practice and sensory feedback could be systematically manipulated to provide the most appropriate, individualized motor retraining program.Main Outcome Measures: Cortical activation and associated motor recovery were measured before and after VR using functional magnetic resonance imaging and standardized motor tests, respectively. Nonparametric tests were used at P less than .05.Results: Prior to VR, the bilateral primary sensorimotor cortices (SM1s), contralesional premotor cortex, and contralesional or ipsilesional supplementary motor area were activated. After VR, the altered activations disappeared and predominantly the ipsilesional SM1 was activated (P