The common heat shock protein receptor CD91 is up‐regulated on monocytes of advanced melanoma slow progressors
The common heat shock protein receptor CD91 is up‐regulated on monocytes of advanced melanoma slow progressors
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常见热休克蛋白受体 CD91 在晚期黑色素瘤缓慢进展者的单核细胞上表达上调
DOI：
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发表时间：
2004
影响因子：
4.6
通讯作者：
J. Spicer
中科院分区：
文献类型：
--
作者：
J. Stebbing;M. Bower;B. Gazzard;A. Wildfire;H. Pandha;A. Dalgleish;J. Spicer
尽管我们对肿瘤免疫学的理解取得了进展，但目前还没有一种疗法可以证明对晚期黑色素瘤具有生存益处。然而，一小部分转移性黑色素瘤患者的疾病进展缓慢，表明宿主因素对结果有贡献。最近的数据表明热休克蛋白受体 CD91 在传染病的免疫反应和进展中的重要性。在这里，我们研究 CD91 表达与恶性肿瘤结果之间的关系。罕见的黑色素瘤患者被招募为进展异常缓慢的晚期疾病。将他们的单核细胞上的 CD91 表达与患有更典型的快速进展转移性疾病的对照患者进行比较。两组中的 Th1 和 Th2 细胞因子以及先天性和适应性免疫子集也进行了测量。在缓慢进展者中观察到中位 CD91 表达水平显着增加 (P = 0·006)。其他免疫子集标记物或炎症细胞因子没有差异。 CD91 通过主要组织相容性复合物 I 类途径内化和交叉呈递肿瘤抗原的能力可能维持 CD8 阳性细胞毒性 T 细胞反应，并有助于减缓晚期黑色素瘤的进展。
Despite advances in our understanding of tumour immunology there is no therapy of proven survival benefit for advanced melanoma. Nevertheless, disease progression is slow in a small proportion of patients with metastatic melanoma, suggesting a contribution to outcome from host factors. Recent data have indicated the importance of the heat shock protein receptor CD91 in immune responses to, and progression of, infectious disease. Here we investigate the relationship between CD91 expression and outcome in malignancy. Rare melanoma patients were recruited with advanced disease that was progressing unusually slowly. CD91 expression on their monocytes was compared with control patients with more typical rapidly advancing metastatic disease. Th1 and Th2 cytokines, as well as innate and adaptive immune subsets, were also measured in the two groups. A significant increase in median CD91 expression levels was observed in slow progressors (P = 0·006). There were no differences in other immune subset markers or inflammatory cytokines. The ability of CD91 to internalize and cross‐present tumour antigens through the major histocompatibility complex class I pathway may maintain CD8‐positive cytotoxic T cell responses and contribute to slow progression of advanced melanoma.
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DOI：
10.1093/jnci/94.12.894
发表时间：
2002-06-19
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Bishop, DT;Demenais, F;Tucker, MA
通讯作者：
Tucker, MA
影响因子：
32.4
作者：
Basu, S;Binder, RJ;Srivastava, PK
通讯作者：
Srivastava, PK
DOI：
10.1056/nejm199710303371803
发表时间：
1997-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
L. Musey;J. Hughes;T. Schacker;T. Shea;L. Corey;L. Corey;M. McElrath;M. McElrath
通讯作者：
L. Musey;J. Hughes;T. Schacker;T. Shea;L. Corey;L. Corey;M. McElrath;M. McElrath
谷胱甘肽 S-转移酶 M1 和 T1 基因型与恶性黑色素瘤的相互作用。
DOI：
--
发表时间：
2001
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Kanetsky,PA;Holmes,R;Walker,A;Najarian,D;Swoyer,J;Guerry,D;Halpern,A;Rebbeck,TR
通讯作者：
Rebbeck,TR