Development of graded hydroxyapatite/CaCO3 composite structures for bone ingrowth
Development of graded hydroxyapatite/CaCO3 composite structures for bone ingrowth
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DOI：
10.1007/s10856-007-3028-3
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发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
Hoffman, M.
中科院分区：
文献类型：
--
作者：
Heilmann, F.;Standard, O. C.;Hoffman, M.
由具有不同骨细胞反应的成分组成的陶瓷复合材料是一种有趣的新型骨替代材料。这项研究中使用的复合材料的第一种成分羟基磷灰石被自然组织取代的速度明显慢于第二种成分碳酸钙，后者的结构稳定性有限。采用滑动渗透和浸渍包覆相结合的方法，从多孔的聚氨酯海绵复制品中制备了具有双峰分布的梯度羟基磷灰石/碳酸钙复合材料。制备了孔隙率为5%~90%的梯度羟基磷灰石支架，然后用碳酸钙泥浆渗透并烧结。通过压碎和模数测试，所得复合材料的力学性能比整体有所改善。
Ceramic composites composed of constituents with different bone cell reactions present an interesting consideration for a new bone replacement material. The first component of the composite used in this study, hydroxyapatite, is known to be replaced by natural tissue significantly slower than the second, calcium carbonate, which has limited structural stability. A graded hydroxy-apatite/calcium carbonate composite with bimodal component distribution was developed using a combined slip infiltration and dip-coating technique from a porous polyurethane sponge replica. A graded hydroxyapatite scaffold with porosities from 5 to 90% was produced and then infiltrated with a calcium carbonate slip and sintered. The resultant composite had improved mechanical properties compared with the monolith as measured by crushing and moduli tests.