Highly oxygenated stigmastane-type steroids from the aerial parts of Vernonia anthelmintica Willd
Highly oxygenated stigmastane-type steroids from the aerial parts of Vernonia anthelmintica Willd
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来自驱虫斑鸠菊地上部分的高氧豆甾烷型类固醇
DOI：
10.1016/j.steroids.2012.03.003
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发表时间：
2012-06-01
期刊：
影响因子：
2.7
通讯作者：
Arfan, Mohammad
中科院分区：
文献类型：
--
作者：
Hua, Lei;Qi, Wei-Yan;Arfan, Mohammad
Nine new highly oxygenated stigmastane-type steroids, vernoanthelcin A-I (1-9), and two new,stigmastane-type steroidal glycosides, vernoantheloside A and B (10 and 11) were isolated from the aerial parts of Vernonia anthelmintica Wind. The structures of compounds 1-11 were determined on the basis of IR, MS, 1D-NMR, and 2D-NMR, and their absolute configurations were deduced using single-crystal X-ray diffraction and the CD exciton chirality method. Compounds 1, 5, 7, 9 and 10 were tested for their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells). Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
