FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia
FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia
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DOI：
10.1046/j.1365-2141.2003.04032.x
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发表时间：
2003-01-01
影响因子：
6.5
通讯作者：
Biondi, A
中科院分区：
文献类型：
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作者：
Arrigoni, P;Beretta, C;Biondi, A
我们评估了诊断超过15年的儿童急性髓性白血病（AML）中FLT 3/内部串联重复（ITD）突变的发生率。FLT 3/ITD在45例非急性早幼粒细胞白血病（non-APL）患者中发现10例（22.2%）。FLT 3/ITD阴性患者的5年无事件生存率高于FLT 3/ITD阳性患者（48.9%，SE 8.9 vs 20.0%，SE 16.1，P = 0.03）。在儿童APL中，FLT 3/ITD的发生率高于非APL，但无统计学意义（29例患者中有10例，34.5%，P = 0.29）。在APL患者中，FLT 3/ITD与诊断时较高的白色血细胞计数和M3法国-美国-英国亚型密切相关。
We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant (10 out of 29 patients, 34.5%, P = 0.29). In APL patients, FLT3/ITD was strongly correlated to a higher white blood cell count at diagnosis and the M3 French-American-British subtype.