Adaptation of Escherichia coli to the bovine mammary gland
Adaptation of Escherichia coli to the bovine mammary gland
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DOI：
10.1128/jcm.39.5.1845-1849.2001
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发表时间：
2001-05-01
影响因子：
9.4
通讯作者：
Green, MJ
中科院分区：
文献类型：
--
作者：
Bradley, AJ;Green, MJ
对六个萨默塞特奶牛群的临床乳房炎进行了为期12个月的监测。34.7%的临床病例与大肠埃希菌有关。41%的临床大肠埃希菌乳腺炎病例仅发生在2.2%的人口中。临床病例中，23.9%的病例发生在复发病例所在的地区。采用肠道细菌重复基因间共有的DNA指纹图谱，对临床复发病例中涉及的菌株进行了基因分型比较。在85.7%的复发性E季度结肠性乳腺炎病例中，相同的基因被认为是疾病的原因，这表明该有机体在乳腺环境中持续存在。8.5%的复发病例也涉及与原始病例相同的基因，这些病例发生在同一头奶牛的不同季度，表明在不同季度之间传播。这些发现挑战了我们目前对大肠杆菌乳房炎流行病学的理解，并表明病原体适应和宿主易感性可能在现代奶牛群中临床乳房炎模式的变化中发挥了作用。
Clinical mastitis in six Somerset dairy herds was monitored over a 12-month period. Escherichia coli was implicated in 34.7% of all clinical eases. Forty-one percent of all clinical E. coli mastitis cases occurred in just 2.2% of the population. A total of 23.9% of clinical E, coli cases occurred in quarters suffering recurrent eases of E, coli mastitis. The genotypes of strains involved in recurrent cases of clinical E, coli mastitis were compared by DNA fingerprinting with enterobacterial repetitive intergenic consensus primers. In 85.7% of cases of recurrent quarter E, coli mastitis, the same genotype was implicated as the cause of disease, suggesting persistence of the organism within the mammary environment. The same genotype as that in the original case was also implicated in 8.5% of recurrent cases occurring in different quarters of the same cow, suggesting spread between quarters. These findings challenge our current understanding of the epidemiology of E, coli mastitis and suggest that pathogen adaptation and host susceptibility may be playing a part in the changing pattern of clinical mastitis experienced in the modern dairy herd.