A mathematical model of ion movements in grey matter during a stroke
A mathematical model of ion movements in grey matter during a stroke
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DOI：
10.1016/j.jtbi.2005.10.023
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发表时间：
2006-06-21
影响因子：
2
通讯作者：
Grenier, Emmanuel
中科院分区：
文献类型：
--
作者：
Dronne, Marie-Aimee;Boissel, Jean-Pierre;Grenier, Emmanuel
中风期间细胞毒性水肿的发展包括细胞肿胀和细胞外间隙的收缩。这种现象是由离子运动通过电压门控通道触发的。交换器和泵。在缺血期间，钠、钙和氯进入神经元，而钾和谷氨酸被排出细胞。本文提出了一个数学模型来描述中风时细胞膜电位、细胞膜电位和细胞内外离子浓度的长期动态变化，并研究了各离子电流对细胞肿胀的影响。该模型依赖于电生理机制，并考虑到两种类型细胞的行为：神经元和星形胶质细胞，已知它们在灰质的兴奋性毒性过程中发挥关键作用。当模拟严重或中度缺血时获得的结果与体外和体内实验中观察到的结果一致。因为这个模型看起来很可靠。它用于进行旨在研究某些通道阻断剂对细胞肿胀的影响的说明性模拟。这种方法可能有助于探索新的治疗策略，以减少中风的损害。(c)2005爱思唯尔有限公司保留所有权利。
The development of cytotoxic oedema during a stroke consists in cell swelling and shrinking of the extracellular space. This phenomenon is triggered by ion movements through voltage-gated channels. exchangers and pumps. During ischaemia, sodium, calcium and chloride enter the neurons whereas potassium and glutamate are expelled out of the cells. A mathematical model is proposed to represent the long-term dynamics of membrane potentials, Cell Volumes and ionic concentrations in intracellular and extracellular spaces during a stroke and to study the influence of each ionic current on cell swelling. The model relies on electrophysiological mechanisms and takes into account the behaviour of two types of cells: neurons and also astrocytes known to play a key role in the excitotoxic process in grey matter. The results obtained when a severe or a moderate ischaemia is simulated are consistent with those observed in the in vitro and in vivo experiments. As this model appears to be robust. it is used to perform illustrative simulations aimed at studying the effect of some channel blockers on cell swelling. This approach may help to explore new therapeutic strategies in order to reduce stroke damage. (c) 2005 Elsevier Ltd. All rights reserved.