Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
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反复与母亲分离对青春期大鼠的认知、情绪和神经化学影响
DOI：
10.1016/j.brainres.2013.04.026
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发表时间：
2013-06-26
期刊：
影响因子：
2.9
通讯作者：
Wang, Weiwen
中科院分区：
文献类型：
--
作者：
Li, Man;Xue, Xiaofang;Wang, Weiwen
作为一种不良的早期生活经历，母亲分离（MS）会导致严重的神经化学、认知和情绪功能障碍。先前的研究报道 MS 影响成年大鼠的前脉冲抑制 (PPI)、焦虑相关行为、多巴胺能和血清素能活性，在本研究中，我们研究了出生后第 1-21 天重复（4 小时/天）母亲分离对高架十字迷宫中 PPI 和焦虑相关行为的影响，以及内侧前额叶中多巴胺 D2 受体 (DRD2) 和 5-HT1A 受体表达的影响青春期大鼠的皮层（mPFC）、伏隔核（NAc）和海马。我们的研究结果表明，重复 MS 会导致青春期大鼠 PPI 降低、焦虑相关行为增加、NAc 和海马中 DRD2 蛋白表达降低，以及 mPFC 和海马中 5-HT1A 蛋白表达降低。这些数据进一步证明MS可以作为神经精神疾病的动物模型。 (c) 2013 Elsevier B.V. 保留所有权利。
As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved.