Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study
Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study
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DOI：
10.1038/sj.eye.6700374
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发表时间：
2003-08-01
期刊：
影响因子：
3.9
通讯作者：
Sasaki, K
中科院分区：
文献类型：
--
作者：
Jonasson, F;Damji, K;Sasaki, K
目的建立雷克雅未克市开角型青光眼（OAG）合并假性剥脱（PEX）的年龄和性别特异性患病率。方法参与雷克雅未克眼科研究的50岁及以上青光眼患者分为三类：第1类：根据视神经立体照片阅读，有以下两种或两种以上：垂直杯盘比（VCDR）97.5th百分位数（>0.7）、局灶性青光眼性视盘改变、眼间C/D不对称97.5th百分位数差异（>0.2）以及青光眼性视野缺损（GVFD）。第2类：99.5百分位数的VCDR（>0.8）和99.5%百分位数的眼间差异（大于或等于0.3），无GVFD。第三类：VA第99.5百分位数或VA第99.5百分位数（>0.8），局灶性青光眼性椎间盘改变，C/D不对称性第99.5百分位数（大于或等于0.3），仅GVFD，IOP大于或等于23 mmHg（97.5百分位数）。结果42例（男22例，女20例）OAG患者中，13例（31.0%）有PEX。50岁及以上人群中OAG的最低患病率为4.0%（42/1045）（95% CI 2.8 - 5.2），PEX为10.3%（95% CI 8.5 - 12.2）。OAG患病率随年龄增长而增加（OR = 1.10/年，95% CI 1.07 ~ 1.13，P = 0.000），PEX患病率随年龄增长而增加（OR = 1.10/年，95% CI 1.07 ~ 1.12，P = 0.000）。
Purpose To establish the age- and sex-specific prevalence of open-angle glaucoma (OAG) subsuming pseudoexfoliation (PEX) in the city of Reykjavik.Methods Participants 50 years of age and older who were part of the Reykjavik Eye Study and classified as having glaucoma were divided into three categories: Category 1: two or more of the following based on optic nerve stereophotograph reading: vertical cup to disc ratio (VCDR) 97.5th percentile (>0.7), focal glaucomatous disc change, C/D asymmetry of 97.5th percentile difference between eyes (>0.2) as well as glaucomatous visual field defect (GVFD). Category 2: 99.5th percentile of VCDR (>0.8) and 99.5% percentile difference between eyes (greater than or equal to0.3), without a GVFD. Category 3: VA 99.5th percentile or VA 99.5th percentile (>0.8), focal glaucomatous disc change, C/D asymmetry of 99.5th percentile (greater than or equal to0.3), GVFD only, IOP greater than or equal to 23 mmHg (97.5 percentile). PEX was diagnosed by the presence of a central shield and/or a peripheral band on the anterior lens capsule.Results Of 42 persons ( 22 males and 20 females) with OAG, 13 (31.0%) had PEX. The minimum prevalence of OAG was 4.0% (42/1045) (95% CI 2.8 - 5.2) for those 50 years and older and 10.3% ( 95% CI 8.5 - 12.2) for PEX. The prevalence of OAG increases with age ( OR = 1.10/year, 95% CI 1.07 - 1.13, P = 0.000) and the same applies for the prevalence of PEX, OR = 1.10 ( 95% CI 1.07 - 1.12, P = 0.000).Conclusion There is a 10% annual increase for both OAG and PEX in persons 50 years and older.