Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
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DOI：
10.1038/ng.175
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发表时间：
2008-08-01
期刊：
影响因子：
30.8
通讯作者：
Daly, Mark J.
中科院分区：
文献类型：
--
作者：
Barrett, Jeffrey C.;Hansoul, Sarah;Daly, Mark J.
在最近的全基因组关联研究中，已经确定了克罗恩病的几个危险因素。为了进一步推进基因发现，我们结合了三项克罗恩病研究的数据（总共3230例病例和4829例对照），并在3664例独立病例中进行了基于人群和基于家庭的混合对照的复制。结果有力地证实了先前报道的11个基因座，并为另外21个基因座提供了全基因组的重要证据，包括包含STAT3、JAK2、ICOSLG、CDKAL1和ITLN1的区域。扩大对这种疾病基础的分子理解为知情的治疗发展提供了希望。
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.