Closing in on a breast cancer gene on chromosome 17q.
Closing in on a breast cancer gene on chromosome 17q.
复制标题
DOI：
--
复制
发表时间：
1992-06
影响因子：
9.8
通讯作者：
Jeff Hall;L. Friedman;C. Guenther;Ming K. Lee;J. Weber;D. Black;M. King
中科院分区：
文献类型：
--
作者：
Jeff Hall;L. Friedman;C. Guenther;Ming K. Lee;J. Weber;D. Black;M. King
早发性家族性乳腺癌和卵巢癌与染色体17 q12-q21上的11个标记物的连锁定义了一个8-cM的区域，该区域很可能包括疾病基因BRCA 1。最紧密连锁的标记是D17 S579，这是一种高度信息化的CA重复多态性。D17 S579在7个早发性疾病家族的79个信息性减数分裂中没有与遗传性乳腺癌或卵巢癌的重组体（在零重组时lod得分为9.12）。没有证据表明早发性疾病的家庭中存在连锁异质性。由于遗传和散发病例都发生在老年发病的家族中，因此，BRCA 1在老年发病的乳腺癌中所占的比例尚不能确定。
Linkage of early-onset familial breast and ovarian cancer to 11 markers on chromosome 17q12-q21 defines an 8-cM region which is very likely to include the disease gene BRCA 1. The most closely linked marker is D17S579, a highly informative CA repeat polymorphism. D17S579 has no recombinants with inherited breast or ovarian cancer in 79 informative meioses in the seven families with early-onset disease (lod score 9.12 at zero recombination). There is no evidence for linkage heterogeneity in the families with early-onset disease. The proportion of older-onset breast cancer attributable to BRCA 1 is not yet determinable, because both inherited and sporadic cases occur in older-onset families.