Factors and pathways involved in capacitation: how are they regulated?
Factors and pathways involved in capacitation: how are they regulated?
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与获能有关的因素和途径：它们是如何调节的？
DOI：
10.18632/oncotarget.12274
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发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Yang WX
中科院分区：
文献类型：
--
作者：
Jin SK;Yang WX
在哺乳动物中，受精是通过一系列事件的综合进展而发生的。新鲜射精的精子尚未获得渐进的运动能力或受精能力。它们必须首先经历一系列生化和生理变化，统称为获能。获能是受精的重要先决条件。在获能过程中，膜特性、细胞内离子浓度和酶活性的变化以及其他蛋白质修饰，在体外确定的培养基或体内女性生殖道中诱导多种信号事件和途径。这些反过来又刺激顶体反应，并为精子在受精前穿透卵子透明带做好准备。在本综述中，我们得出了调节获能的所有主流因素和途径的结论，并强调了它们的串扰。我们还总结了获能与辅助生殖技术或人类疾病之间的关系。最后，我们总结了该领域的悬而未决的问题和未来的途径。
In mammals, fertilization occurs via a comprehensive progression of events. Freshly ejaculated sperm have yet to acquire progressive motility or fertilization ability. They must first undergo a series of biochemical and physiological changes, collectively known as capacitation. Capacitation is a significant prerequisite to fertilization. During the process of capacitation, changes in membrane properties, intracellular ion concentration and the activities of enzymes, together with other protein modifications, induce multiple signaling events and pathways in defined media in vitro or in the female reproductive tract in vivo. These, in turn, stimulate the acrosome reaction and prepare spermatozoa for penetration of the egg zona pellucida prior to fertilization. In the present review, we conclude all mainstream factors and pathways regulate capacitation and highlight their crosstalk. We also summarize the relationship between capacitation and assisted reproductive technology or human disease. In the end, we sum up the open questions and future avenues in this field.