Maturation of nuclear lamin A involves a specific carboxy‐terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina
Maturation of nuclear lamin A involves a specific carboxy‐terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina
复制标题
核层 A 的成熟涉及特定的羧基末端修剪，从对核层结构产生影响的前体中去除聚异戊二烯化位点；
DOI：
10.1016/0014-5793(89)81584-4
复制
发表时间：
1989
期刊：
影响因子：
3.5
通讯作者：
P. Traub
中科院分区：
文献类型：
--
作者：
K. Weber;U. Plessmann;P. Traub
Lamin A, a nuclear lamina protein of differentiated cells, is synthesized as a precursor of the mature molecule. Protein sequencing of the carboxyterminal 14 kDa fragment shows a lack of the last 18 residues predicted by cDNA sequencing. The carboxy-terminal proteolytic maturation explains previous biochemical results including the loss of the polyisoprenylation site now located to the CXXM motif at the end of the chain. This view and earlier results on lamin B predict multiple post-translational modifications shared by lamins A and B. While retained by lamin B, which is present in all cells, they are lost by maturation from lamin A, which probably acts only as an additional lamina constituent in differentiated cells.
甲羟戊酸产物修饰核纤层蛋白 B 的证据。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wolda,SL;Glomset,JA
通讯作者：
Glomset,JA