Effects of diesel exhaust inhalation on heart rate variability in human volunteers
Effects of diesel exhaust inhalation on heart rate variability in human volunteers
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DOI：
10.1016/j.envres.2008.01.012
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发表时间：
2008-06-01
影响因子：
8.3
通讯作者：
Sullivan, Jeffrey H.
中科院分区：
文献类型：
--
作者：
Peretz, Alon;Kaufman, Joel D.;Sullivan, Jeffrey H.
目的：在流行病学研究中，颗粒物（PM）空气污染与心脏传导性改变和心脏性猝死有关。包括柴油机废气（DE）在内的与废气有关的空气污染物可能至少是造成这些影响的部分原因。在这项实验研究中，我们评估了短期暴露于DE是否会导致心率变异性（HRV）的改变，心率变异性是一种无创性的心脏自主控制措施。在一项双盲、交叉、受控暴露研究中，16名成年志愿者（休息时）随机暴露于过滤空气（FA）和两种水平的稀释DE（100或200 μ g/m3的细颗粒物）在2小时的会议。在每次暴露前和暴露后的四个时间点，我们评估了HRV。评估的HRV参数包括时域统计量和（N-N间隔的标准差（SDNN）和连续N-N间隔之间的平方差之和（RMSSD）的平均值的平方根）和频域统计（高频（HF）功率、低频（LF）功率和LF/HF比）。我们观察到的影响，在3小时后开始DE吸入频域统计的HRV。与FA相比，200 μ g/m3的DE引起HF功率增加（Delta = 0.33; 95% CI：0.01-0.7），LF/HF比值降低（Delta = -0.74; 95% CI：-1.2至-0.2）。DE对HF功率的影响在研究参与者中并不一致。有没有DE的影响时域统计和没有显着的DE效应对HRV在以后的时间points.Conclusions：我们没有观察到一致的DE效应的自主控制的心脏在一个控制曝光实验中的年轻参与者。有必要努力了解空气污染对HRV影响的流行病学和实验研究之间的差异。(C)2008年爱思唯尔公司All rights reserved.
Objectives: Particulate matter (PM) air pollution is associated with alterations in cardiac conductance and sudden cardiac death in epidemiological studies. Traffic-related air pollutants, including diesel exhaust (DE) may be at least partly responsible for these effects. In this experimental study we assessed whether short-term exposure to DE would result in alterations in heart rate variability (HRV), a non-invasive measure of autonomic control of the heart.Methods: In a double-blind, crossover, controlled-exposure study, 16 adult volunteers were exposed (at rest) in randomized order to filtered air (FA) and two levels of diluted DE (100 or 200 mu g/m(3) of fine particulate matter) in 2-h sessions. Before, and at four time points after each exposure we assessed HRV. HRV parameters assessed included both time domain statistics (standard deviation of N-N intervals (SDNN), and the square root of the mean of the sum of squared differences between successive N-N intervals (RMSSD)) and frequency domain statistics (high-frequency (HF) power, low-frequency (LF) power, and the LF/HF ratio).Results: We observed an effect at 3-h after initiation of DE inhalation on the frequency domain statistics of HRV. DE at 200 mu g/m(3) elicited an increase in HF power compared to FA (Delta = 0.33; 95% CI: 0.01-0.7) and a decrease in LF/HF ratio (Delta = -0.74; 95% CI: -1.2 to -0.2). The effect of DE on HF power was not consistent among study participants. There was no DE effect on time domain statistics and no significant DE effect on HRV in later time points.Conclusions: We did not observe a consistent DE effect on the autonomic control of the heart in a controlled-expo sure experiment in young participants. Efforts are warranted to understand discrepancies between epidemiological and experimental studies of air pollution's impact on HRV. (C) 2008 Elsevier Inc. All rights reserved.