A Meta-Analysis of 67 Studies with Presenting Symptoms and Laboratory Tests of COVID-19 Patients
A Meta-Analysis of 67 Studies with Presenting Symptoms and Laboratory Tests of COVID-19 Patients
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DOI：
10.1002/lary.29207
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发表时间：
2020-11-06
期刊：
影响因子：
2.6
通讯作者：
Das, Sudip
中科院分区：
文献类型：
--
作者：
Mair, Manish;Singhavi, Hitesh;Das, Sudip
目的/假设本荟萃分析的目的是观察所有COVID-19感染患者的症状、实验室检查和影像学检查的汇总患病率。研究设计Meta分析方法我们检索了PubMed、EMBASE和奥维德三个数据库，以识别2019年12月至2020年5月期间发表的研究。纳入了所有报告COVID-19感染的上呼吸消化道症状的研究。荟萃分析进行了流行病学观察性研究（MOOSE）的指导方针，其中评估了合并患病率的14个症状和9个实验室investigation.Results的基础上纳入标准，67篇文章，包括8302例患者的荟萃分析。在成人中，高血压和糖尿病患者的合并比例分别为18%和7%。咳嗽（53% [0.46-0.61]）、嗅觉丧失（38% [0.19-0.58]）、味觉丧失/扭曲（31% [0.17-0.45]）和鼻塞（26% [0.12-0.39]）是最常见的耳鼻咽喉（ENT）症状。发热（69% [0.62-0.76]）和乏力（31% [0.26-0.37]）是最常见的全身症状。C-反应蛋白（CRP）和血沉（ESR）分别升高56%（0.41-0.71）和49%（0.21-0.77）。有趣的是，淋巴细胞减少症（41% [0.30-0.53]）和白细胞减少症（22% [0.16-0.29]）比淋巴细胞增多症（33% [0.02-0.64]）和白细胞增多症（12% [0.09-0.16]）更常见。与儿科人群相比，发热（69% vs. 44%）、咳嗽（53% vs. 33%）和呼吸困难（20% vs. 4%）在成人中更常见。腹泻在儿科病例中更常见（12%）与（9%）。死亡率汇总估计为4%。结论最常见的耳鼻喉科症状是咳嗽，其次是嗅觉丧失和味觉障碍。ESR和CRP升高伴白细胞减少和淋巴细胞减少是常见的实验室检查结果。大多数感染患者有异常的计算机断层扫描结果。COVID感染在儿科患者中不太严重。喉镜，2020
Objectives/Hypothesis The objective of this meta-analysis was to look at the pooled prevalence of symptoms, laboratory tests, and imaging of all COVID-19 infected patients. This will allow better identification of potential COVID-19 patients and take appropriate precautions.Study design Meta analysis.Methods We searched three databases, PubMed, EMBASE, and Ovid to identify studies published between Dec-2019 and May-2020. All studies reporting upper-aerodigestive symptoms of COVID-19 infection were included. The meta-analysis was conducted following meta-analyses of observational studies in epidemiology (MOOSE) guidelines, which have evaluated the pooled prevalence of 14 symptoms and nine laboratory investigations.Results Based on inclusion criteria, 67 publications consisting of 8302 patients were included. Among adults, the pooled proportion of hypertensive and diabetic patients was 18% and 7%. Cough (53% [0.46-0.61]), anosmia (38% [0.19-0.58]), loss/distortion of taste (31% [0.17-0.45]), and nasal obstruction (26% [0.12-0.39]) were the most common ear, nose & throat (ENT) symptoms. Fever (69% [0.62-0.76]) and fatigue (31% [0.26-0.37]) were the commonest generalized symptoms. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were raised in 56% (0.41-0.71) and 49% (0.21-0.77), respectively. Interestingly, lymphopenia (41% [0.30-0.53]) and leucopenia (22% [0.16-0.29]) were more common than lymphocytosis (33% [0.02-0.64]) and leucocytosis (12% [0.09-0.16]). Fever (69% vs. 44%), cough (53% vs. 33%), and dyspnea (20% vs. 4%) were more common in adults as compared to the pediatric population. Diarrhea was more common among the pediatric cases (12%) versus (9%). The pooled estimate of fatality was 4%.Conclusions The most commonly experienced ENT symptom was cough followed by anosmia and dysguesia. Raised ESR and CRP with leukopenia and lymphopenia are common laboratory findings. Majority of the infected patients had abnormal computed tomography findings. COVID infection is less severe in pediatric patients. Laryngoscope, 2020