[Aortic strain and distensibility in patients with metabolic syndrome].
[Aortic strain and distensibility in patients with metabolic syndrome].
复制标题
[代谢综合征患者的主动脉应变和扩张]。
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Ş. Korkmaz
中科院分区：
文献类型：
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作者：
Y. Güray;Meltem Refiker;B. Demirkan;U. Güray;Ayça Boyacı;Ş. Korkmaz
目标
代谢综合征(METS)与心血管疾病风险增加有关。我们用超声心动图评估了METS患者的主动脉僵硬及其影响因素。
研究设计
根据ATP-III标准，这项研究包括27名患者(18名男性，9名女性；平均年龄56±7.5岁)和33名患者(20名男性，13名女性；平均年龄54.3±5.5岁)。测量血压、脉压、腰围，以及总胆固醇、高密度脂蛋白和低密度脂蛋白、甘油三酯和超敏C反应蛋白(hs-CRP)水平。用M型超声心动图从胸骨旁长轴切面测量升主动脉的收缩内径和舒张期内径，并计算主动脉僵硬参数(主动脉应变和扩张性)。
结果
与对照组相比，甲亢组患者的血压、脉压、腰围显著升高，甘油三酯、血糖、hs-CRP水平显著升高，高密度脂蛋白水平显著降低(p<；0.05)。甲硫氨酸组的主动脉张力(9.0+/-3.5%vs.6.3+/-3.8%；p=0.007)显著增加，而主动脉扩张性(2.70±-1.9 cm(2)/dyn/10(3)vs.4.8+/-1.9 cm(2)/dyn/10(3)p=0.001)显著降低。主动脉扩张性与年龄(r=-0.269，p=0.03)、超敏C反应蛋白(r=-0.287，p=0.002)、收缩压(r=-0.533，p<；0.001)、舒张压(r=-0.275，p=0.03)呈负相关。在年龄调整的多元回归分析中，收缩压(β=0.80，P<0.001)、腰围(β=0.5，P=0.02)和超敏C反应蛋白(β=0.6，P=0.002)是主动脉扩张性的独立预测因素。
结论
甲状旁腺素患者的主动脉僵硬程度增加。使用一种无创且容易获得的工具--经胸超声心动图，可以很容易地评估动脉僵硬，因此可以通过对危险因素的适当治疗来降低心血管疾病的发生率和相关死亡率。
OBJECTIVES
Metabolic syndrome (MetS) is associated with increased risk for cardiovascular disease. We evaluated aortic stiffness and factors affecting aortic stiffness by echocardiography in patients with MetS.
STUDY DESIGN
The study included 27 patients (18 men, 9 women; mean age 56+/-7.5 years) and 33 patients (20 men, 13 women; mean age 54.3+/-5.5 years) with and without MetS, respectively, according to the ATP-III criteria. Blood pressure, pulse pressure, waist circumference, and levels of total cholesterol, HDL and LDL cholesterol, triglyceride, and high-sensitivity C-reactive protein (hs-CRP) were measured. Systolic and diastolic diameters of the ascending aorta were measured by M-mode echocardiography from the parasternal long-axis views, and parameters of aortic stiffness (aortic strain and distensibility) were calculated.
RESULTS
Compared to the control group, patients with MetS had significantly higher values of blood pressure, pulse pressure, waist circumference, and higher triglyceride, glucose, and hs-CRP levels and lower HDL cholesterol level (p<0.05). In the MetS group, aortic strain (9.0+/-3.5% vs. 6.3+/-3.8%; p=0.007) was significantly increased and aortic distensibility (2.7+/-1.9 cm(2)/dyn/10(3) vs. 4.8+/-1.9 cm(2)/dyn/10(3) p=0.001) was significantly decreased. Aortic distensibility was negatively correlated with age (r=-0.269, p=0.03), hs-CRP (r=-0.287, p=0.002), systolic blood pressure (r=-0.533, p<0.001), and diastolic blood pressure (r=-0.275, p=0.03). In age-adjusted multiple regression analysis, systolic blood pressure (beta=0.8, p<0.001), waist circumference (beta=0.5, p=0.02), and hs-CRP (beta=0.6, p=0.002) were independent predictors of aortic distensibility.
CONCLUSION
Aortic stiffness is increased in patients with MetS. Using a noninvasive and readily available tool, transthoracic echocardiography, arterial stiffness can easily be assessed, so that the incidence of cardiovascular diseases and associated mortality can be decreased through appropriate treatment for risk factors.