Differential inhibition of fat intake in two strains of rat by the peptide enterostatin.
Differential inhibition of fat intake in two strains of rat by the peptide enterostatin.
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肽肠抑素对两种大鼠品系脂肪摄入的差异抑制。
DOI：
10.1152/ajpregu.1992.262.6.r1111
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
C. Erlanson‐Albertsson
中科院分区：
文献类型：
--
作者：
S. Okada;D. York;G. Bray;J. Mei;C. Erlanson‐Albertsson
在两个品系的大鼠中研究了肠抑素（胰腺前脂酶的氨基末端五肽）对食物摄入的影响，所述两个品系的大鼠是膳食脂肪敏感的Osstell-Mendel（OM）大鼠和膳食脂肪抵抗的S5 B/Pl大鼠。禁食过夜后，肠抑素抑制OM大鼠摄入高脂（HF）但不抑制低脂（LF）饮食，但对S5 B/P1大鼠无影响。当喂食大量营养素三选择饮食时，OM大鼠优先选择脂肪，而S5 B/Pl大鼠选择碳水化合物。肠抑素特异性抑制OM大鼠的脂肪摄入，但不S5 B/P1大鼠喂养三种选择的大量营养素饮食。与OM大鼠相比，HF和LF饮食的S5 B/P1大鼠的胰腺Colipase活性增加。在三种选择的大量营养素饮食中，胰腺辅脂酶活性与脂肪的自愿摄入量呈负相关。这些数据支持肠抑素可能控制膳食脂肪摄入的假设。
The effect of enterostatin, the amino-terminal pentapeptide of pancreatic procolipase, on food intake was investigated in two strains of rat, the dietary fat-sensitive Osborne-Mendel (OM) rat and the dietary fat-resistant S5B/Pl rat. After an overnight fast, enterostatin inhibited intake of high-fat (HF) but not low-fat (LF) diets in OM rats, but had no effect in S5B/Pl rats. When fed a macronutrient three-choice diet, OM rats selected fat preferentially, whereas S5B/Pl rats selected carbohydrate. Enterostatin specifically inhibited the intake of fat in OM rats but not S5B/Pl rats fed a three-choice macronutrient diet. The activity of pancreatic colipase was increased in S5B/Pl rats on both HF and LF diets compared with OM rats. Pancreatic colipase activities were negatively related to the voluntary intake of fat on three-choice macronutrient diets. The data support the hypothesis that enterostatin may control the intake of dietary fat.