Oestrogen‐induced sensitization of the uterine artery of the guinea‐pig to acetylcholine
Oestrogen‐induced sensitization of the uterine artery of the guinea‐pig to acetylcholine
复制标题
雌激素诱导豚鼠子宫动脉对乙酰胆碱的敏感性
DOI：
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发表时间：
1973
影响因子：
7.3
通讯作者：
C. Bell
中科院分区：
文献类型：
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作者：
C. Bell
1 先前已表明，豚鼠子宫动脉因乙酰胆碱或胆碱能血管舒张神经刺激而扩张仅发生在怀孕期间。现在已经进行了实验来确定这种反应性变化的激素基础。 2 通过肌内注射或皮下植入雌二醇对处女豚鼠进行长期治疗，导致子宫动脉对乙酰胆碱产生反应，其程度与怀孕期间发生的反应程度相似。 3 同时给予黄体酮并没有显着抑制这种雌激素作用。相反，雌激素对子宫生长和脂肪分解代谢的特有作用被黄体酮完全拮抗。 4 其他工作人员确定，怀孕期间子宫动脉乙酰胆碱反应性的发展时间过程与雌激素产生和胎盘血流量的增加是平行的。这支持了胆碱能扩张神经参与妊娠期间子宫充血并且其功能受母体血液雌激素水平调节的概念。
1 It has been shown previously that a dilatation of the uterine artery of the guinea‐pig in response to acetylcholine or to stimulation of cholinergic vasodilator nerves occurs only during pregnancy. Experiments have now been performed to determine the hormonal basis of this change in responsiveness. 2 Chronic treatment of virgin guinea‐pigs with oestradiol, either by intramuscular injection or by subcutaneous implantation, caused the development of a responsiveness of the uterine artery to acetylcholine which was similar in degree to that occurring during pregnancy. 3 Simultaneous administration of progesterone did not significantly inhibit this oestrogen effect. In contrast the characteristic actions of oestrogen on uterine growth and fat catabolism were completely antagonized by progesterone. 4 The time course of the development of responsiveness to acetylcholine of the uterine arteries during pregnancy was parallel to the rises in oestrogen production and placental blood flow as determined by other workers. This supports the concept that cholinergic dilator nerves participate in uterine hyperaemia during pregnancy and that their functioning is regulated by the maternal blood oestrogen level.