α-Amylase triggered-carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella
α-Amylase triggered-carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella
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基于环糊精锚定中空介孔二氧化硅的α-淀粉酶触发载体增强阿维菌素对小菜蛾的杀虫活性
DOI：
10.1016/j.jhazmat.2018.07.059
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发表时间：
2018-10-05
影响因子：
13.6
通讯作者：
He, Shun
中科院分区：
文献类型：
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作者：
Kaziem, Amir E.;Gao, Yunhao;He, Shun
以α-环糊精(α-CD)为封端分子，锚定中空介孔二氧化硅(HMS)为载体，制备了阿维菌素(AVM)α-淀粉酶响应型控释载体。考察了不同温度、不同pH值、有无α-淀粉酶的条件下AVM的释放情况。结果表明，AVM-CRF具有强烈的酶依赖性，包封率高达38%，具有良好的紫外线和热屏蔽能力。AVM-CRF生物活性测定表明：对小菜蛾幼虫具有良好的毒理作用，证实了α-CD帽在体内能被酶解帽，释放出AVM，诱导小菜蛾幼虫死亡。Avm-CRF对L-1 Avm的生物活性为0.6 mg，持续到第14天，靶虫死亡率为83.33%，比Avm商用制剂高40%。本研究为农药减量的应用提供了理论依据。
alpha-Amylase-responsive carrier for controlled release of avermectin (AVM) was prepared based on alpha-cyclodextrin (alpha-CD) anchored hollow mesoporous silica (HMS) using alpha-CD as a capping molecule. The release of AVM was studied at different temperatures, pH values and in the presence or absence of alpha-amylase. The results revealed that the AVM-encapsulated controlled release formulation (AVM-CRF) has a drastic enzymatic dependence, an excellent encapsulation efficacy reaching 38%, and outstanding UV and thermal shielding ability. The AVM-CRF biological activity survey shows :excellent toxicological properties against Plutella xylostella larvae, which confirms that alpha-CD caps could be uncapped enzymatically in vivo and release AVM, inducing P. xylostella larval death. AVM-CRF has a notable capability to keep 0.6 mg L-1 AVM biologically active until 14th day with 83.33% mortality of the target insect, which was 40% higher than that of treated with AVM commercial formulation. The study provides a theoretical basis for the application of pesticide reduction.