An inhibitor of the binding of thyroid hormones to serum proteins is present in extrathyroidal tissues.
An inhibitor of the binding of thyroid hormones to serum proteins is present in extrathyroidal tissues.
复制标题
甲状腺激素与血清蛋白结合的抑制剂存在于甲状腺外组织中。
DOI：
10.1126/science.7058324
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Eisenberg,JB
中科院分区：
文献类型：
--
作者：
Chopra,IJ;Solomon,DH;Teco,GN;Eisenberg,JB
人和大鼠的甲状腺外组织含有一种有效的抑制甲状腺激素与血清蛋白和阴离子交换树脂结合的抑制剂。该缓蚀剂不耐热，不能透析。它的作用是通过降低甲状腺激素与血清蛋白的结合亲和力，而不是通过减少结合位点的数量。这种组织抑制物在几个特征上与之前在一些危重患者的血清中描述的抑制物相似，这表明在严重疾病中组织抑制物可能会泄漏到循环中。
Extrathyroidal tissues of man and the rat contain a potent inhibitor of the binding of thyroid hormones to serum proteins and to an anion-exchange resin. The inhibitor is heat-labile and nondialyzable. It acts by reducing the binding affinity of thyroid hormones to serum proteins, not by reducing the number of binding sites. The tissue inhibitor is similar in several characteristics to an inhibitor described previously in the serum of some critically ill patients, suggesting that the tissue inhibitor may leak into the circulation in severe illnesses.