In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs
In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs
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DOI：
10.4269/ajtmh.2001.65.450
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Kawamoto, F
中科院分区：
文献类型：
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作者：
Wongsrichanalai, C;Lin, K;Kawamoto, F
在体外药物敏感性资料进行了评估，在75恶性疟原虫分离株从4个地点在缅甸。除了在毛淡棉，最接近泰国边境的网站，流行和耐甲氟喹的程度较低，缅甸分离株相比，从泰国。抑制50%（IC 50）和90%（IC 90）Mawlamyine分离株的几何平均浓度分别为51 nM（95%置信区间[CI]，40-65）和124 nM（95% CI，104-149）。在最近的泰国研究中心Maesod，已知高水平的多药耐药性，甲氟喹的IC 50和IC 90的相应值分别为92 nM（95% CI，71-121）和172 nM（95% CI，140-211）。除Mawlamyine外，缅甸恶性疟原虫对甲氟喹的敏感性与半免疫人群的临床寄生虫学疗效一致。在这一地理区域观察到对青蒿素化合物的高度敏感性。数据表明，高度甲氟喹耐药的恶性疟原虫集中在泰缅边境地区的一部分。
In vitro drug susceptibility profiles were assessed in 75 Plasmodium falciparum isolates from 4 sites in Myanmar. Except at Mawlamyine, the site closest to the Thai border, prevalence and degree of resistance to mefloquine were lower among the Myanmar isolates as compared with those from Thailand. Geometric mean concentration that inhibits 50% (IC50) and 90% (IC90) of Mawlamyine isolates were 51 nM (95% confidence interval [CI], 40-65) and 124 nM (95% Cl, 104-149), respectively. At the nearest Thai site, Maesod, known for high-level multidrug resistance, the corresponding values for mefloquine IC50 and IC90 were 92 nM (95% Cl, 71-121) and 172 nM (95% CI, 140-211). Mefloquine susceptibility of P. falciparum in Myanmar, except for Mawlamyine, was consistent with clinical-parasitological efficacy in semi-immune people. High sensitivity to artemisinin compounds was observed in this geographical region. The data suggest that highly mefloquine-resistant P. falciparum is concentrated in a part of the Thai-Myanmar border region.