Are immunoglobulin E levels associated with early wheezing? A prospective study in Brazilian infants
Are immunoglobulin E levels associated with early wheezing? A prospective study in Brazilian infants
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DOI：
10.1183/09031936.02.00219302
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发表时间：
2002-09-01
影响因子：
24.3
通讯作者：
Ribeiro, JD
中科院分区：
文献类型：
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作者：
Lopez, N;de Barros-Mazon, S;Ribeiro, JD
喘息或哮喘与早期血清免疫球蛋白(Ig)E水平的关系尚不清楚。这项研究的目的是跟踪观察在出生后第一年出现或没有出现反复喘息的婴儿的IgE免疫反应。研究对象为102名随机抽取的足月新生儿，分别在3个月、6个月、9个月和12个月大的脐带血样本中测定IgE水平。在6个月和12个月时，还评估了食物和吸入性过敏原的特异性IgE水平以及吸入性过敏原的皮肤点刺试验。在临床随访期间，32名(31%)婴儿出现两次或更多喘息发作，而70名(69%)婴儿没有喘息。与非喘息组相比，喘息组12个月内的总IgE水平显著升高。在12个月时，反复喘息的婴儿对牛奶、蛋清和尘螨的特异性IgE水平较高。特应性疾病家族史对血清IgE水平无影响。在6个月和12个月大的喘息型婴儿中，皮肤点刺试验的阳性率分别为14%和23%。这些结果表明喘息型婴儿早期出现过敏反应，表明免疫调节T细胞在免疫球蛋白E产生中的作用发生了变化。
The relationship between wheezing or asthma and serum immunoglobulin (Ig)E levels in early life is unclear. The aim of this study was to follow-up the IgE immune response in infants that did, or did not, develop recurrent wheezing during their first year of life.One-hundred and two randomised term neonates were included, in which IgE levels were quantified in cord blood samples, at 3, 6, 9 and 12 months of age. Specific IgE levels for food and inhalant allergens and the skin-prick test for inhalant allergens were also assessed at 6 and 12 months.During clinical follow-up, 32 (31%) infants presented with two or more wheezing episodes, while 70 (69%) had no wheezing. Total IgE levels were significantly higher up to 12 months in wheezing infants when compared to nonwheezing group. At 12 months, the specific IgE levels to cow's milk, egg white and mites were higher in infants with recurrent wheezing. There was no influence of family history for atopy on IgE levels. The skin-prick tests were positive in 14% and 23% in wheezing infants at 6 and 12 months, respectively.These results indicate an early allergic sensitisation in wheezing infants, suggesting an altered immunoregulatory T-cell role in immunoglobulin E production.