Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhone-Alpes region, France, January to August 2014: implications for antiviral treatment
Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhone-Alpes region, France, January to August 2014: implications for antiviral treatment
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DOI：
10.2807/1560-7917.es2014.19.43.20944
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发表时间：
2014-10-30
期刊：
影响因子：
19
通讯作者：
Larrat, S.
中科院分区：
文献类型：
--
作者：
Ramiere, C.;Tremeaux, P.;Larrat, S.
自2014年初以来，在法国罗讷-阿尔卑斯地区10名来自高加索地区的患者中检测到了丙型肝炎病毒（HCV）重组型RF2k/1b。这种特定 HCV 毒株的循环很可能被低估。使用基于病毒基因组 5' 区域的基因分型方法时，也容易出现基因分型错误，这可能导致治疗效果不佳。在此，我们报告了在法国罗讷-阿尔卑斯地区里昂和格勒诺布尔大学医院的两个病毒学实验室中检测到的 10 名患者感染了丙型肝炎病毒 (HCV) 特定重组形式 (RF) RF2k/1b。
Since the beginning of 2014, hepatitis C virus (HCV) recombinant forms RF2k/1b have been detected in the Rhone-Alpes French region in 10 patients originating from the Caucasus area. Circulation of this particular HCV strain is very likely to be underestimated. It is also prone to be misgenotyped when using genotyping methods based on the 5' region of the viral genome, which may lead to suboptimal treatment.Here we report the detection of 10 patients infected with a particular recombinant form (RF) of hepatitis C virus (HCV), RF2k/1b, in two virology laboratories in the university hospitals in Lyon and Grenoble in the Rhone-Alpes region, France.