Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters
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DOI：
10.1016/j.neurobiolaging.2011.05.012
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发表时间：
2012-08-01
影响因子：
4.2
通讯作者：
Baumgaertner, Wolfgang
中科院分区：
文献类型：
--
作者：
Gerhauser, Ingo;Wohlsein, Peter;Baumgaertner, Wolfgang
叙利亚金仓鼠 (Mesocricetus auratus) 是兼性冬眠者，预期寿命约为 2 年。先前的研究表明，tau 蛋白在冬眠和衰老过程中会过度磷酸化，这让人们希望叙利亚仓鼠可能成为研究阿尔茨海默病发病机制的有用动物模型。使用组织学和免疫组织化学研究了 190 只 1-36 月龄仓鼠的大脑和脊髓横断面，以检测神经原纤维缠结和/或弥漫性以及神经炎斑块。总之，不存在淀粉样蛋白沉积、神经原纤维缠结以及弥漫性和神经炎斑块，这表明叙利亚金仓鼠即使在高龄也不会出现阿尔茨海默氏病的特征性变化，并且不能代表这种疾病的合适动物模型。 (C) 2012 Elsevier Inc. 保留所有权利。
Syrian golden hamsters (Mesocricetus auratus) are facultative hibernators with a life expectancy of approximately 2 years. Previous investigations showed a hyperphosphorylation of the tau protein during hibernation and aging and raised hopes that Syrian hamsters might represent a useful animal model to study pathogenetic mechanisms of Alzheimer's disease. Brain and spinal cord transversal sections of 190 hamsters 1-36 months of age were investigated using histology and immunohistochemistry to detect neurofibrillary tangles and/or diffuse as well as neuritic plaques. Summarized, amyloid deposition, neurofibrillary tangles, and diffuse as well as neuritic plaques were absent indicating that the Syrian golden hamster does not develop changes characteristic of Alzheimer's disease even at advanced age and does not represent an appropriate animal model for this disease. (C) 2012 Elsevier Inc. All rights reserved.