The Effect of Cytotoxic Drugs on Neutrophil Phagocytosis in Vitro and in Patients with Acute Myelogenous Leukaemia
The Effect of Cytotoxic Drugs on Neutrophil Phagocytosis in Vitro and in Patients with Acute Myelogenous Leukaemia
复制标题
细胞毒性药物对体外和急性髓性白血病患者中性粒细胞吞噬作用的影响
DOI：
10.1111/j.1365-2141.1976.tb01871.x
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发表时间：
1976
影响因子：
6.5
通讯作者：
M. Khurshid
中科院分区：
文献类型：
--
作者：
J. E. Davies;J. Whittaker;M. Khurshid
The in vitro effects of a range of concentrations of cyclophosphamide, doxorubicin, actinomycin D, cytarabine and methotrexate on neutrophil phagocytosis of C. albicans was studied. The reduction in phagocytic index (PI) was inversely proportional to the dilution of the drug and there was some inhibition of phagocytosis at all dilutions of all drugs. In patients with acute myelogenous leukaemia (AML), in vivo experiments showed that remission chemotherapy of doxorubicin or daunorubicin together with cytosine arabinoside increasingly inhibited phagocytosis over the period studied. The importance of these findings in the chemotherapy of malignant disease and the possible mode of action of cytotoxic drugs are discussed.
