Can guideline-defined asthma control be achieved? The gaining optimal asthma control study
Can guideline-defined asthma control be achieved? The gaining optimal asthma control study
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DOI：
10.1164/rccm.200401-033oc
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发表时间：
2004-10-15
影响因子：
24.7
通讯作者：
Pedersen, SE
中科院分区：
文献类型：
--
作者：
Bateman, ED;Boushey, HA;Pedersen, SE
对于大多数患者来说，哮喘没有得到指南定义的控制；这是否可以实现还没有前瞻性的研究。对3421名未控制哮喘患者进行为期一年的随机、分层、双盲、平行分组研究，比较丙酸氟替卡松和沙美特罗/氟替卡松在实现两种严格、复合、基于指南的控制措施方面的效果：完全控制哮喘和良好控制哮喘。逐步进行治疗，直到完全控制(或每天两次最多500杯皮质类固醇)。使用沙美特罗/氟替卡松的每一层患者(以前不使用皮质类固醇、低剂量和中剂量皮质类固醇使用者)获得控制的患者明显多于氟替卡松。所有层面的患者都得到了完全控制：520名(31%)患者在剂量递增后与326名(19%)患者相比(p
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively studied. A 1-year, randomized, stratified, double-blind, parallel-group study of 3,421 patients with uncontrolled asthma compared fluticasone propionate and salmeterol/fluticasone in achieving two rigorous, composite, guideline-based measures of control: totally and well-controlled asthma. Treatment was stepped-up until total control was achieved (or maximum 500 mug corticosteroid twice a day). Significantly more patients in each stratum (previously corticosteroid-free, low- and moderate-dose corticosteroid users) achieved control with salmeterol/fluticasone than fluticasone. Total control was achieved across all strata: 520 (31%) versus 326 (19%) patients after dose escalation (p