Basic Fibroblast Growth Factor as a Candidate Tumor Marker for Renal Cell Carcinoma
Basic Fibroblast Growth Factor as a Candidate Tumor Marker for Renal Cell Carcinoma
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碱性成纤维细胞生长因子作为肾细胞癌的候选肿瘤标志物
DOI：
10.1111/j.1349-7006.1995.tb03037.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
E. Okajima
中科院分区：
文献类型：
--
作者：
K. Fujimoto;Y. Ichimori;H. Yamaguchi;K. Arai;T. Futami;S. Ozono;Y. Hirao;T. Kakizoe;M. Terada;E. Okajima
本研究旨在通过酶免疫测定法测定各种泌尿生殖肿瘤患者的碱性成纤维细胞生长因子（FGF）血清水平。肾细胞癌比任何其他泌尿生殖系统肿瘤具有更高的血清碱性 FGF 水平升高的趋势（52 例中的 28 例，53.8%），并且在晚期肾细胞癌患者中更频繁地检测到血清碱性 FGF 升高。组织学模式分析表明，具有实性或管状成分的肾细胞癌更有可能产生碱性FGF。然而，透明细胞型肿瘤患者血清碱性FGF升高的比例(50.0%)与颗粒细胞型肿瘤患者血清碱性FGF升高的比例(66.7%)之间没有显着差异。 8 名肾细胞癌患者中，有 5 名在肾切除术前接受选择性肾静脉取样，结果显示患肾肾静脉中血清碱性 FGF 升高。切除受影响的肾脏以去除癌症后，血清碱性 FGF 在 2 周内消失。然而，2例患者因残余巨大肿瘤或术后疾病延长了碱性FGF水平的升高，表明碱性FGF是由肿瘤组织本身产生和分泌的。这些发现表明血清碱性 FGF 可用于肾细胞癌患者的诊断和评估预后。
The present investigation was conducted to determine serum levels of basic fibroblast growth factor (FGF) by enzyme immunoassay in patients with various urogenital tumors. Renal cell carcinoma had a higher tendency (28 of 52, 53.8%) toward increased serum levels of basic FGF than any of the other urogenital tumors, and increased serum basic FGF was detected more frequently in patients with advanced renal cell carcinoma. Analysis of histological pattern indicated that renal cell carcinoma with a solid or tubular component is more likely to produce basic FGF. However, no significant difference was seen between the percentage of clear cell type tumor patients with increased serum basic FGF (50.0%) and the percentage of granular cell type tumor patients with increased serum basic FGF (66.7%). Five of 8 patients with renal cell carcinoma who underwent selective renal venous sampling before nephrectomy showed increased serum basic FGF in the renal vein from the affected kidney. After resection of the affected kidney to remove the cancer, serum basic FGF disappeared within 2 weeks. However, residual huge tumor or postoperative disease prolonged the increased levels of basic FGF in 2 patients, indicating that basic FGF is produced from and secreted by tumor tissue itself. These findings suggest that serum basic FGF can be useful in the diagnosis, and in evaluating the prognosis, of patients with renal cell carcinoma.
影响因子：
11.2
作者：
Y. Yamanaka;H. Friess;M. Büchler;H. Beger;E. Uchida;M. Onda;M. Kobrin;M. Korc
通讯作者：
Y. Yamanaka;H. Friess;M. Büchler;H. Beger;E. Uchida;M. Onda;M. Kobrin;M. Korc
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J
尿液中可检测到动物肿瘤分泌的碱性成纤维细胞生长因子。
影响因子：
11.2
作者：
Soutter,AD;Nguyen,M;Watanabe,H;Folkman,J
通讯作者：
Folkman,J