Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans.
Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans.
复制标题
DOI：
10.1152/jappl.1989.66.6.2778
复制
发表时间：
1989-06
影响因子：
3.3
通讯作者：
R. Rea;B. Wallin
中科院分区：
文献类型：
--
作者：
R. Rea;B. Wallin
据报道，非膨胀性下体负压（LBNP）可减少前臂血流量，但不会减少小腿血流量，如应变计体积描记法所测量。这表明心肺感受器的卸载增加了交感神经流出到手臂，但不是腿。为了验证这一假设，我们测量了肌肉交感神经活动（MSA）在手臂（桡神经）和腿部（腓神经）同时在LBNP。在8名健康受试者中，我们在10和20 mmHg的LBNP下测量心率、血压、桡动脉和腓动脉MSA。静息状态下桡神经和腓神经MSA无差异，LBNP在10和20 mmHg时，两条神经的MSA连续平行增加。这些数据表明，有几乎相同的增加交感神经流出到手臂和腿在轻度到中度的立位应力。
Nonhypotensive lower body negative pressure (LBNP) is reported to decrease forearm but not calf blood flow as measured by strain-gauge plethysmography. This suggests that unloading of cardiopulmonary receptors increases sympathetic outflow to arm but not to leg. To test this hypothesis we measured muscle sympathetic nerve activity (MSA) in the arm (radial nerve) and leg (peroneal nerve) simultaneously during LBNP. In eight healthy subjects, we measured heart rate, blood pressure, and radial and peroneal MSA during LBNP at 10 and 20 mmHg. There was no difference between radial and peroneal MSA at rest, and there were successive parallel increases of MSA in both nerves during LBNP at 10 and 20 mmHg. These data indicate that there are nearly identical increases of sympathetic outflow to the arm and leg during mild to moderate degrees of orthostatic stress.