A pilot genetic study of the continuum between compulsivity and impulsivity in females:: The serotonin transporter promoter polymorphism
A pilot genetic study of the continuum between compulsivity and impulsivity in females:: The serotonin transporter promoter polymorphism
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DOI：
10.1016/j.pnpbp.2005.04.019
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发表时间：
2005-06-01
影响因子：
5.6
通讯作者：
de Leon, J
中科院分区：
文献类型：
--
作者：
Baca-García, E;Salgado, BR;de Leon, J
根据一些作者的说法，强迫症谱系包括一个极端，强迫症（OCD）和另一个极端，最冲动的行为。这是一个有争议的观点，其他作者以不同的方式定义了OC谱。5-羟色胺转运蛋白（5-HTT）基因是控制血清素功能的主要基因之一。该基因启动子区域的多态性将低表达者分类为S个体（S / S或S /l），高表达者分类为l个体（1/1）。该多态性在女性强迫症患者（n=24）、非冲动型对照（n=112）和冲动型自杀患者（n=118）中进行了研究，从遗传学角度支持OC谱假说。5 -羟色胺转运子启动子功能基因型之间存在线性关联（S与L个体）(chi(2)线性关联= 8.9；Df = 1；P = 0.003)。S /l或S / S的出现频率在强迫症中最低（54%,13/24）；非冲动性控制组居中（71%,80/112），冲动性自杀企图者最高（82%,96/117）。更重要的是，未来的研究需要考虑到遗传学可能与行为维度（从强迫到冲动）有关，而不是与临床术语定义的特定精神疾病有关。(C) 2005爱思唯尔公司版权所有。
According to some authors the obsessive-compulsive (OC) spectrum includes on one extreme, the obsessive-Compulsive Disorder (OCD) and on the other extreme the most impulsive behaviors. This is a controversial idea and other authors define the OC spectrum in different ways. The serotonin transporter (5-HTT) gene is one of the main genes that control serotonergic function. A polymorphism in the promoter area of this gene classifies subjects with low expression as S individuals (s/s or s/l) and subjects with high expression as L individuals (1/1). This polymorphism was studied in female OCD patients (n=24), non-impulsive controls (n=112) and impulsive suicidal patients (n=118) to support the OC spectrum hypothesis from a genetic perspective. A linear association exists among the serotonin transporter promoter functional genotypes (S versus L individuals) (chi(2) linear by linear association = 8.9; df = 1; p = 0.003). The frequency of S individuals (s/l or s/s) was lowest in OCD (54%, 13/24); intermediate in non-impulsive controls (71%, 80/112) and highest in impulsive suicide attempters (82%, 96/117). More importantly, future studies need to consider that genetics may be related to behavioral dimensions (compulsivity to impulsivity) instead of to specific psychiatric disorders defined in clinical terms. (C) 2005 Elsevier Inc. All rights reserved.