Pneumocystis carinii pneumonia: successful diagnosis treatment of two patients with associated malignant processes.
Pneumocystis carinii pneumonia: successful diagnosis treatment of two patients with associated malignant processes.
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卡氏肺囊虫肺炎：成功诊断治疗两名伴有相关恶性过程的患者。
DOI：
10.1056/nejm196902062800602
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
C. Berard
中科院分区：
文献类型：
--
作者：
V. Devita;M. Emmer;A. Levine;B. Jacobs;C. Berard
两名潜在淋巴网状恶性病变的患者被成功地用异硫氰酸戊双胺治疗卡氏肺孢子虫肺炎。经皮肺穿活检确诊为肺孢子虫感染。两名患者在治疗过程中都出现了肾功能下降；其中一名患者似乎主要是肾小管功能障碍，这与剂量增加的异硫代戊二胺有关，但这种情况是可逆的。在适当的临床环境下，应强烈怀疑这种感染，进行肺活检，并给予适当的治疗。在有组织学记录的病例中，进一步使用异硫戊双胺的经验将使对其疗效的有效评估成为可能。使用异硫酸戊胺的医生应该预料到其潜在的肾脏毒性。
Two patients with underlying lymphoreticular malignant processes were successfully treated for documentedPneumocystis cariniipneumonia with pentamidine isethionate. The diagnosis of pneumocystis infection was confirmed in each case by percutaneous pulmonary needle biopsy. Decreased renal function occurred on therapy in both patients; in one, this seemed to be primarily a tubular disorder that was related to increased dose of pentamidine isethionate and that was reversible.In the proper clinical setting, this infection should be strongly suspected, a pulmonary needle biopsy performed, and adequate therapy given. Further experience with pentamidine isethionate in histologically documented cases will permit a valid assessment of its therapeutic efficacy. Physicians using pentamide isethionate should anticipate its potential renal toxicity.